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Special Issue "Novel Biorelevant Intestinal Epithelial In Vitro Models"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 31 July 2021.

Special Issue Editors

Dr. Kati Juuti-Uusitalo
E-Mail Website
Guest Editor
Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
Interests: patient derived induced pluripotent stem cells; intestinal epithelial cell differentiation; barrier function; celiac disease; type 1 diabetes
Dr. Keijo Viiri
E-Mail Website
Guest Editor
Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
Interests: intestinal epigenetics; genome-wide analyses; intestinal signalling; intestinal organoids; celiac disease

Special Issue Information

Dear Colleagues,

We are delighted to announce that we are now accepting submissions for the upcoming Special Issue of the International Journal of Molecular Sciences on the topic of Novel Biorelevant Intestinal Epithelial In Vitro Models. The human small intestine is responsible for multiple functions, such as the absorption of nutrients, vitamins or drugs; the transportation of electrolytes; the secretion of biologically active peptide hormones; the formation of an impermeable barrier against viruses and microbes; and even the formation of direct synapses with sensory neurons. Previously, functional assays have been hampered by the low biological resemblance of the in vitro models to actual small intestinal tissue. In recent years, several novel small intestinal in vitro and organotypic ex vivo models, which bear a stronger resemblance to the in vivo tissue than conventional models, have emerged. Many of these novel models are based on patient stem cells, are cultured three-dimensionally, can be co-cultured with several other cell types with which they are known to interact in vivo (e.g., immune and neuronal cells) and thus represent more suitable means of assessing several aspects of intestinal epithelial functionality, such as the gut–brain axis and the effects of the microbiome on intestinal functionality, as well as studying drug absorption and metabolism in several small intestinal diseases.  

We encourage submission of both original research articles and topical reviews on all aspects of novel biorelevant intestinal epithelial in vitro models and their exploitation in endeavours to study the abovementioned aspects. All submitted articles will undergo peer review.

Dr. Kati Juuti-Uusitalo
Dr. Keijo Viiri
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • patient-derived stem cell models
  • microfluidic organ-on-a-chip models of human intestine
  • intestinal organoids
  • gut–brain axis
  • microbiome assays
  • drug delivery assays
  • gastrointestinal hormones
  • intestinal diseases

Published Papers

This special issue is now open for submission.
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