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Ionic Liquids Toxicity: Past, Present and Future

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Toxicology".

Deadline for manuscript submissions: closed (31 May 2022) | Viewed by 2153

Special Issue Editors


E-Mail Website
Guest Editor
Centro de Química Estrutural, Faculdade de Ciências, Universidade de Lisboa, Lisbon, Portugal
Interests: ionic liquids; toxicity; molecular toxicology; antimicrobial activity

E-Mail Website
Guest Editor
Centro de Química Estrutural, Faculdade de Ciências, Universidade de Lisboa, Lisbon, Portugal
Interests: ionic liquids; toxicity; molecular toxicology; antimicrobial activity

Special Issue Information

Dear Colleagues,

Ionic liquids (ILs) are an example of a continuously growing field due to their variety and consequently their numerous applications. For this reason, the number of publications concerning this type of chemicals has grown exponentially. In the past five years more than 36000 publications referring to ILs covering different areas have been published. Initially hailed as a green alternative to traditional solvents, it is now common knowledge that they are not as green as desired, and more thought has to be put into the biological consequences of their industrial use. Still, compared to the amount of research studying their physicochemical properties and potential applications in different commercial areas, there is a distinct scarcity of scientific papers investigating how these substances interact with the different organisms that are part of an ecosystem. The purpose of this special issue is to look into the most emergent studies on their toxicity, as well as gather and unify all the existing knowledge on this hot topic. This special issue will change the insight about how ILs can help shape a more sustainable future.

Dr. Santos Fernando J.V.
Dr. Xavier Paredes
Guest Editors

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Keywords

  • ionic liquids
  • toxicity
  • ecotoxicity
  • phytotoxicity
  • antimicrobial activity
  • biodegradation
  • toxicity modeling

Published Papers (1 paper)

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Research

12 pages, 16126 KiB  
Article
Neurotoxicity of Chronic Co-Exposure of Lead and Ionic Liquid in Common Carp: Synergistic or Antagonistic?
by Weikai Ding, Yousef Sultan, Shumei Li, Wenjun Wen, Bangjun Zhang, Yiyi Feng, Junguo Ma and Xiaoyu Li
Int. J. Mol. Sci. 2022, 23(11), 6282; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms23116282 - 03 Jun 2022
Cited by 6 | Viewed by 1658
Abstract
Previous studies have indicated that the harmful heavy metal lead (Pb) contamination in aquatic systems has caused intelligence development disorders and nervous system function abnormalities in juveniles due to the increased permeability of the blood–brain barrier. Ionic liquids (ILs) are considered “green” organic [...] Read more.
Previous studies have indicated that the harmful heavy metal lead (Pb) contamination in aquatic systems has caused intelligence development disorders and nervous system function abnormalities in juveniles due to the increased permeability of the blood–brain barrier. Ionic liquids (ILs) are considered “green” organic solvents that can replace traditional organic solvents. Studies have found the presence of ILs in soil and water due to chemical applications or unintentional leakage. Therefore, what would happen if Pb interacted with ILs in a body of water? Could ILs enable Pb to more easily cross the blood–brain barrier? Therefore, we examined the combined exposure of Pb and ILs in common carp at low concentration (18.3 mg L−1 of Pb(CH3COO)2•3 H2O and 11 mg L−1 of the IL 1-methyl-3-octylimidazolium chloride, 5% of their LC50) for 28 days in the present study. The result of a neurobehavioral assay showed that chronic exposure of lead at lower concentrations significantly altered fish movement and neurobehaviors, indicating that lead exposure caused neurotoxicity in the carp. Increases in the neurotransmitter dopamine levels and injuries in the fish brain accounted for neurobehavioral abnormalities induced by lead exposure. Moreover, we also found that lead could easily cross the blood–brain barrier and caused significant bioaccumulation in the brain. Particularly, our study indicated that the ionic liquid could not synergistically promote blood–brain barrier permeability and hence failed to increase the absorption of lead in the fish brain, suggesting that the combined exposure of lead and ILs was not a synergistic effect but antagonism to the neurotoxicity. The results of this study suggested that ILs could recede the Pb induced neurotoxicity in fish. Full article
(This article belongs to the Special Issue Ionic Liquids Toxicity: Past, Present and Future)
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