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Special Issue "Novel Aspects in Kidney Disease in Diabetes 2.0"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: 31 October 2021.

Special Issue Editor

Prof. Dr. Giuseppina T. Russo
E-Mail Website
Guest Editor
Department of Clinical and Experimental Medicine, Policlinico Universitario “G. Martino”, Via Consolare Valeria, 98124 Messina, Italy
Interests: diabetes; diabetic kidney disease; gender medicine; macrovascular disease; lipid metabolism; homocysteine; genetics
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Special Issue Information

Dear Colleagues,

Diabetes mellitus (DM) affects millions of people worldwide, and ~40% of them may have diabetic nephropathy.

We are witnessing a dramatic change in the pathophysiology, management and therapeutic approach of diabetic nephropathy, now termed kidney disease associated with DM. Accumulating evidence has recently been focused on clarifying the different morphological and pathophysiological aspects of renal lesions associated with diabetes, especially the non-albuminuric phenotype. There is still an ongoing debate on the prevalence and the role of different forms of kidney disease in diabetic subjects, other than diabetic kidney disease and the potential biomarkers able to distinguish among them, when the biopsy is not feasible. Renewed hope comes from the recent evidences from experimental research, and from cardiovascular outcomes trials (CVOTs), which have demonstrated the benefits of the new classes of hypoglycemic drugs on the occurrence and progression of kidney disease as well as on cardiovascular disease (CVD) risk. Finally, the high CVD risk in DM subjects with kidney disease calls for the urgent need to translate basic research into clinical practice, in order to help people with DM to survive longer and without the specter of dialysis in front of them.

This Special Issue will deal with several aspects of diabetes and its renal complications, as specified below. We welcome original research articles, comprehensive reviews and short communications with a focus on molecular level studies.

Potential topics include, but are not limited to, the relationship between kidney disease associated with diabetes with:

1. Sex/gender differences;

2. Renal morphology changes in diabetic patients;

3. Differences between Type 1 and type 2 diabetes;

4. Role of genetics/omics

5. Predictive models/artificial intelligence;

6. New biomarkers/new applications of old biomarkers;

7. Phenotyping DKD: isolated low eGFR vs. albuminuria;

8. New approaches with albuminuria: overcoming traditional cut-offs;

9. Role of the renin–angiotensin system and SGT2i;

10. Predictors of fast progression in patients with diabetes mellitus and renal failure;

11. Role of vitamin D status in diabetic patients with renal disease;

12. Management of Diabetic Mellitus in patients with reduced renal function;

13. Oxidative stress/endothelial dysfunction/inflammation and the progression of diabetic nephropathy;

14. Potential beneficial effects of SGTL2 inhibitors and GLP1-RAs and/or their combination;

15. Mineral corticoid receptor antagonist and diabetes mellitus;

16. Ageing, kidney and diabetes management;

17. Cardiovascular risk factors and diabetic kidney;

18. Nutritional aspects in diabetic patients with chronic renal failure.

Prof. Dr. Giuseppina T. Russo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • diabetic kidney disease
  • microalbuminuria
  • gender
  • genetics, omics, artificial intelligence, biomarkers
  • low protein diet in diabetic nephropathy
  • ageing
  • sglt2
  • glp1-ras

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Published Papers

This special issue is now open for submission.
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