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Special Issue "Epigenetic Regulation in Chronic Kidney Disease and Its Complication"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".

Deadline for manuscript submissions: 31 January 2022.

Special Issue Editor

Prof. Dr. Tadashi Yoshida
E-Mail Website
Guest Editor
Apheresis and Dialysis Center, Keio University School of Medicine, Tokyo, Japan
Interests: smooth muscle cells; vascular biology; vascular calcification; transcription factors; epigenetics; end-stage renal disease

Special Issue Information

Dear Colleagues, 

Chronic kidney disease (CKD) is defined by a reduced glomerular filtration rate, increased proteinuria, or both. The prevalence of CKD is estimated to be 8–16% worldwide. Patients with CKD are accompanied by a variety of complications, including anemia, hyperkalemia, hypocalcemia, hyperphosphatemia, secondary hyperparathyroidism, metabolic acidosis, and bone abnormalities. In addition, they are at high risk of cardiovascular disease and death. Thus far, therapeutic approaches to control these abnormal conditions have not been well developed yet. Recently, studies in the field of epigenetics have made significant progress. It has been realized that various epigenetic mechanisms, such as histone modifications, DNA methylation, ubiquitination, microRNAs, noncoding RNAs, etc. play crucial roles in the pathogenesis of multiple disease conditions, including CKD. In this Special Issue of the International Journal of Molecular Sciences, I would like to invite contributions addressing molecular and/or epigenetic mechanisms for the pathogenesis of CKD and its complications. Submissions can be either original research papers or reviews. Your contributions will be highly appreciated.

Prof. Dr. Tadashi Yoshida
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • chronic kidney disease
  • transcription
  • histone modification
  • DNA methylation
  • anemia
  • vascular calcification
  • calcium
  • phosphorus
  • dialysis

Published Papers

This special issue is now open for submission.
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