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Special Issue "Advances in Lipid-Mediated Inflammation-Resolution Mechanisms in Health and Disease"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: closed (31 October 2021).

Special Issue Editors

Dr. Gijs Kooij
E-Mail Website
Guest Editor
MS Center Amsterdam, Department of Molecular Cell Biology and Immunology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, De Boelelaan 1117, 1081 HZ Amsterdam, The Netherlands
Interests: bioactive lipids; specialized proresolving lipid mediators (SPMs); multiple sclerosis (MS); neuroscience; brain barriers; lipidomics; resolution of neuroinflammation
Dr. Valerio Chiurchiù
E-Mail Website
Guest Editor
1. Institute of Translational Pharmacology, National Research Council (CNR), 00133 Rome, Italy
2. Laboratory of Resolution of Neuroinflammation, European Center for Brain Research (CERC)/IRCCS Santa Lucia Foundation, 00143 Rome, Italy
Interests: bioactive lipids; specialized proresolving lipid mediators (SPMs); immunology; innate and adaptive immunity; neuroinflammation; glial cells; multiple sclerosis (MS)
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The acute inflammatory response is host protective and initiated by tissue injury, infection, or exogenous stimuli. During acute inflammation, innate immune cells are recruited to the damaged or infected site and rapidly generate eicosanoids, which are responsible for the so-called “cardinal signs” of inflammation (redness, heat, swelling, pain, and loss of function). This needs to be self-limiting and promptly extinguished upon cessation or elimination of the noxious stimulus. This last process is an active process and is referred to as “resolution of inflammation”, during which immune cells undergo a temporal lipid mediator class switch and start producing specialized proresolving mediators (SPMs). An efficient resolution response is crucial to avoid tissue damage and to drive the restoration of full tissue homeostasis. In turn, uncontrolled or unresolved inflammation is an underlying cause of many chronic diseases and suggests that the resolution response is not functioning properly. Researchers in this field have done an amazing job over recent years, providing astonishing new insights into understanding the complex and coordinated processes that regulate the diverse inflammatory responses and the identification of several classes of resolution-inducing mediators as well as uncovering potential resolution defects in numerous chronic inflammatory diseases.

In this Special Issue, we will focus on the advances in the field of resolution-inducing mediators over the last 10 years, their impact on our overall understanding of resolution of inflammation and how alterations in this protective system aid the development of chronic inflammation in a wide variety of diseases, thereby positioning such mediators as novel therapeutics. We are seeking novel research articles in the field of inflammation-resolution or review articles focused on the topics shown in the keywords below that are dedicated to the developments of the last 10 years and how these have changed and/or enhanced our understanding of proinflammatory/proresolving lipid mediators in various inflammatory diseases. Our aim for this Special Issue is to shine a light on multidisciplinary research that examines how resolution-inducing lipid mediators can be eventually exploited as novel diagnostic and/or therapeutic opportunities to prevent chronic inflammatory diseases.

Dr. Gijs Kooij
Dr. Valerio Chiurchiù
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioactive lipids (eicosanoids, sphingolipids, ceramides, endocannabinoids)
  • specialized proresolving lipid mediators (SPMs)
  • PUFA (omega 3 and omega 6)
  • lipidomics
  • metabolomics
  • lipid biology (biosynthesis, degradation, transport, receptors and signalling)
  • inflammation
  • immunity (innate and adaptive)
  • resolution of inflammation
  • tissue homeostasis
  • chronic inflammation
  • low grade inflammation
  • inflammatory diseases (metabolic, cardiovascular, pulmonary, gastrointestinal, autoimmune, cancer, neurodegenerative)
  • noncommunicable diseases
  • resolution pharmacology

Published Papers (1 paper)

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Review

Review
Anti-Inflammatory Function of Fatty Acids and Involvement of Their Metabolites in the Resolution of Inflammation in Chronic Obstructive Pulmonary Disease
Int. J. Mol. Sci. 2021, 22(23), 12803; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms222312803 (registering DOI) - 26 Nov 2021
Viewed by 112
Abstract
Lipid metabolism plays an important role in many lung functions. Disorders of lipid metabolism are part of the pathogenesis of chronic obstructive pulmonary disease (COPD). Lipids are involved in numerous cross-linkages with inflammation. Recent studies strongly support the involvement of fatty acids as [...] Read more.
Lipid metabolism plays an important role in many lung functions. Disorders of lipid metabolism are part of the pathogenesis of chronic obstructive pulmonary disease (COPD). Lipids are involved in numerous cross-linkages with inflammation. Recent studies strongly support the involvement of fatty acids as participants in inflammation. They are involved in the initiation and resolution of inflammation, including acting as a substrate for the formation of lipid mediators of inflammation resolution. Specialized pro-inflammatory mediators (SPMs) belonging to the classes of lipoxins, resolvins, maresins, and protectins, which are formed enzymatically from unsaturated fatty acids, are now described. Disorders of their production and function are part of the pathogenesis of COPD. SPMs are currently the subject of active research in order to find new drugs. Short-chain fatty acids are another important participant in metabolic and immune processes, and their role in the pathogenesis of COPD is of great clinical interest. Full article
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