Lipopolysaccharides and Innate Immunity: Potential Usefulness
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Macromolecules".
Deadline for manuscript submissions: closed (30 June 2022) | Viewed by 2252
Special Issue Editor
Interests: LPS; function of tissue macrophages; mode of action of oral administration of LPS; cognitive dysfunction; reverse aging
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Lipopolysaccharide (LPS) has historically been referred to as an endotoxin because its intravascular injection induces dramatic inflammatory responses.
However, with the elucidation of the mechanisms of innate immunity, LPS has come to be regarded as a substance that can regulate innate immune function, and thus, play a preventive role against various diseases, including modern ones. For example, it has been demonstrated that LPS exposure is helpful for the prevention of allergic asthma among children; LPS exerts its effects on the mucosal tissues of the oral cavity, intestinal tract, and skin; while antibiotic-induced impairment of innate immune function can be prevented, or immune function may be restored by LPS intake. These factors suggest that a paradigm shift is underway to re-examine the physiological role of LPS.
In this Special Issue, we will focus on the role of LPS as a regulator of innate immune functioning and have introduced basic and applied approaches, with special attention to the potential usefulness of LPS.
The regulation of innate immune functioning will be a crucial issue in the future for the prevention and treatment of various diseases, including the prevention of COVID-19. In this context, it is timely to highlight the powerful innate immune regulatory effects of LPS as a means of maintaining good health.
Dr. Gen-Ichiro Soma
Guest Editor
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Keywords
- oral administration of LPS
- physiological role of LPS
- TLR-4
- mechanism(s) of LPS in control of innate immunity
- structure and functional relationship of LPS
