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Molecular Pathology of Lung Cancer: Current Status and Perspectives

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 2373

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Guest Editor
Pathology Unit, University Hospital of Parma, Parma, Italy
Interests: lung; kidney; gastrointestinal cancer
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Lung cancer is a considerable morphological complexity that is divided into small-cell lung cancer (SCLC) and non-small-cell lung cancer (NSCLC). In solid tumors, molecular targeting and immunotherapy for lung cancer are relatively successful. However, the treatment of patients requires comprehensive molecular diagnosis. The prediction, treatment, and prognosis of lung cancer sometimes involve highly sensitive diagnostic materials and technologies, which bring new challenges to the molecular pathology of lung cancer.

I cordially invite authors to submit original research and review articles to this Special Issue, which addresses the latest progress in and current understanding of the molecular pathology, diagnosis, and treatment of lung cancer.

The topics of this Special Issue include, but are not limited to:

  • Molecular targeted therapy of lung cancer, immune checkpoint inhibitors, and neoadjuvant chemotherapy.
  • Molecular analysis and characterization of lung cancer/lung tissue.
  • Molecular analysis of biomarkers of acquired resistance to specific drugs for lung cancer.

Dr. Letizia Gnetti
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • lung cancer
  • small-cell lung cancer
  • non-small-cell lung cancer
  • molecular targeting
  • immunotherapy
  • molecular analysis

Published Papers (1 paper)

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Research

14 pages, 3670 KiB  
Article
Surveillance of cfDNA Hot Spot Mutations in NSCLC Patients during Disease Progression
by Agne Sestokaite, Vaida Gedvilaite, Saulius Cicenas, Rasa Sabaliauskaite and Sonata Jarmalaite
Int. J. Mol. Sci. 2023, 24(8), 6958; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms24086958 - 09 Apr 2023
Cited by 1 | Viewed by 1640
Abstract
Non-small cell cancer (NSCLC) has been identified with a great variation of mutations that can be surveyed during disease progression. The aim of the study was to identify and monitor lung cancer-specific mutations incidence in cell-free DNA as well as overall plasma cell-free [...] Read more.
Non-small cell cancer (NSCLC) has been identified with a great variation of mutations that can be surveyed during disease progression. The aim of the study was to identify and monitor lung cancer-specific mutations incidence in cell-free DNA as well as overall plasma cell-free DNA load by means of targeted next-generation sequencing. Sequencing libraries were prepared from cell-free DNA (cfDNA) isolated from 72 plasma samples of 41 patients using the Oncomine Lung cfDNA panel covering hot spot regions of 11 genes. Sequencing was performed with the Ion Torrent™ Ion S5™ system. Four genes were detected with highest mutation incidence: KRAS (43.9% of all cases), followed by ALK (36.6%), TP53 (31.7%), and PIK3CA (29.3%). Seven patients had co-occurring KRAS + TP53 (6/41, 14.6%) or KRAS + PIK3CA (7/41, 17.1%) mutations. Moreover, the mutational status of TP53 as well an overall cell-free DNA load were confirmed to be predictors of poor progression-free survival (HR = 2.5 [0.8–7.7]; p = 0.029 and HR = 2.3 [0.9–5.5]; p = 0.029, respectively) in NSCLC patients. In addition, TP53 mutation status significantly predicts shorter overall survival (HR = 3.4 [1.2–9.7]; p < 0.001). We demonstrated that TP53 mutation incidence as well as a cell-free DNA load can be used as biomarkers for NSCLC monitoring and can help to detect the disease progression prior to radiological confirmation of the status. Full article
(This article belongs to the Special Issue Molecular Pathology of Lung Cancer: Current Status and Perspectives)
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