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Special Issue "Group I Metabotropic Glutamate Receptors: Physiological and Pathological Roles"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 30 November 2021.

Special Issue Editors

Dr. Ada Ledonne
E-Mail Website
Guest Editor
Department of Experimental Neuroscience, Foundation Santa Lucia, Rome, Italy
Interests: neurophysiology; neuropharmacology; neurotransmission; synaptic plasticity; dopaminergic system; mGluRI; neuregulins; neuropsychiatric disorders; Parkinson's disease
Prof. Dr. Nicola B. Mercuri
E-Mail Website
Guest Editor
IRCCS Fondazione Santa Lucia, Rome, Italy
Interests: neurodegenerative diseases; autoimmune diseases of the central and peripheral nervous system; neuroprotective drugs

Special Issue Information

Dear Colleagues,

Group I metabotropic glutamate receptors (mGluRI), including mGluR1 and mGluR5 subtypes, are Gq/11-coupled receptors with a widespread expression in the brain. mGluRI are essential for proper brain functioning: they affect neuronal excitability, neurotransmission and synaptic plasticity, thus directly mediating cellular mechanisms underlying learning and memory processes and complex behaviors. Moreover, unbalanced mGluRI-dependent mechanisms have been reported in several neurological and psychiatric illnesses.

The aim of this Special Issue is to collect original papers and reviews to feature recent advances on mGluRI-dependent effects in health and brain diseases. Specifically, manuscripts will be accepted that describe mGluRI signaling and interactome (scaffolding proteins, regulatory proteins and signaling effectors, or mGluRI assembly with other receptors/ion channels), mGluRI functions in neurons and glial cells, their roles in the regulation of synaptic plasticity, learning and memory processes and complex behaviors, both in physiological and pathological conditions, also including neurodevelopmental disorders, neurodegenerative diseases, and psychopathologies.

Dr. Ada Ledonne
Prof. Dr. Nicola Mercuri
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • mGluR1
  • mGluR5
  • mGluRI signaling
  • neurotransmission
  • synaptic plasticity
  • learning and memory
  • behavior
  • neurodevelopmental diseases
  • neurological and psychiatric disorders

Published Papers

This special issue is now open for submission.
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