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Group I Metabotropic Glutamate Receptors: Physiological and Pathological Roles

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: closed (30 November 2021) | Viewed by 4323

Special Issue Editors

Department of Experimental Neuroscience, Foundation Santa Lucia, Rome, Italy
Interests: neurophysiology; neuropharmacology; neurotransmission; synaptic plasticity; dopaminergic system; mGluRI; neuregulins; neuropsychiatric disorders; Parkinson's disease
IRCCS Fondazione Santa Lucia, Rome, Italy
Interests: neurodegenerative diseases; autoimmune diseases of the central and peripheral nervous system; neuroprotective drugs

Special Issue Information

Dear Colleagues,

Group I metabotropic glutamate receptors (mGluRI), including mGluR1 and mGluR5 subtypes, are Gq/11-coupled receptors with a widespread expression in the brain. mGluRI are essential for proper brain functioning: they affect neuronal excitability, neurotransmission and synaptic plasticity, thus directly mediating cellular mechanisms underlying learning and memory processes and complex behaviors. Moreover, unbalanced mGluRI-dependent mechanisms have been reported in several neurological and psychiatric illnesses.

The aim of this Special Issue is to collect original papers and reviews to feature recent advances on mGluRI-dependent effects in health and brain diseases. Specifically, manuscripts will be accepted that describe mGluRI signaling and interactome (scaffolding proteins, regulatory proteins and signaling effectors, or mGluRI assembly with other receptors/ion channels), mGluRI functions in neurons and glial cells, their roles in the regulation of synaptic plasticity, learning and memory processes and complex behaviors, both in physiological and pathological conditions, also including neurodevelopmental disorders, neurodegenerative diseases, and psychopathologies.

Dr. Ada Ledonne
Prof. Dr. Nicola Mercuri
Guest Editors

Manuscript Submission Information

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Keywords

  • mGluR1
  • mGluR5
  • mGluRI signaling
  • neurotransmission
  • synaptic plasticity
  • learning and memory
  • behavior
  • neurodevelopmental diseases
  • neurological and psychiatric disorders

Published Papers (2 papers)

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Review

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15 pages, 1156 KiB  
Review
Group I Metabotropic Glutamate Receptors and Interacting Partners: An Update
by Li-Min Mao, Alaya Bodepudi, Xiang-Ping Chu and John Q. Wang
Int. J. Mol. Sci. 2022, 23(2), 840; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms23020840 - 13 Jan 2022
Cited by 14 | Viewed by 2164
Abstract
Group I metabotropic glutamate (mGlu) receptors (mGlu1/5 subtypes) are G protein-coupled receptors and are broadly expressed in the mammalian brain. These receptors play key roles in the modulation of normal glutamatergic transmission and synaptic plasticity, and abnormal mGlu1/5 signaling is linked to the [...] Read more.
Group I metabotropic glutamate (mGlu) receptors (mGlu1/5 subtypes) are G protein-coupled receptors and are broadly expressed in the mammalian brain. These receptors play key roles in the modulation of normal glutamatergic transmission and synaptic plasticity, and abnormal mGlu1/5 signaling is linked to the pathogenesis and symptomatology of various mental and neurological disorders. Group I mGlu receptors are noticeably regulated via a mechanism involving dynamic protein–protein interactions. Several synaptic protein kinases were recently found to directly bind to the intracellular domains of mGlu1/5 receptors and phosphorylate the receptors at distinct amino acid residues. A variety of scaffolding and adaptor proteins also interact with mGlu1/5. Constitutive or activity-dependent interactions between mGlu1/5 and their interacting partners modulate trafficking, anchoring, and expression of the receptors. The mGlu1/5-associated proteins also finetune the efficacy of mGlu1/5 postreceptor signaling and mGlu1/5-mediated synaptic plasticity. This review analyzes the data from recent studies and provides an update on the biochemical and physiological properties of a set of proteins or molecules that interact with and thus regulate mGlu1/5 receptors. Full article
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8 pages, 663 KiB  
Opinion
Role of Group I Metabotropic Glutamate Receptors in Spike Timing-Dependent Plasticity
by Irene Martínez-Gallego, Antonio Rodríguez-Moreno and Yuniesky Andrade-Talavera
Int. J. Mol. Sci. 2022, 23(14), 7807; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms23147807 - 15 Jul 2022
Cited by 6 | Viewed by 1603
Abstract
Metabotropic glutamate receptors (mGluRs) are G-protein-coupled receptors that exhibit enormous diversity in their expression patterns, sequence homology, pharmacology, biophysical properties and signaling pathways in the brain. In general, mGluRs modulate different traits of neuronal physiology, including excitability and plasticity processes. Particularly, group I [...] Read more.
Metabotropic glutamate receptors (mGluRs) are G-protein-coupled receptors that exhibit enormous diversity in their expression patterns, sequence homology, pharmacology, biophysical properties and signaling pathways in the brain. In general, mGluRs modulate different traits of neuronal physiology, including excitability and plasticity processes. Particularly, group I mGluRs located at the pre- or postsynaptic compartments are involved in spike timing-dependent plasticity (STDP) at hippocampal and neocortical synapses. Their roles of participating in the underlying mechanisms for detection of activity coincidence in STDP induction are debated, and diverse findings support models involving mGluRs in STDP forms in which NMDARs do not operate as classical postsynaptic coincidence detectors. Here, we briefly review the involvement of group I mGluRs in STDP and their possible role as coincidence detectors. Full article
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