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Special Issue "MicroRNAs in Cancer Therapy"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Macromolecules".

Deadline for manuscript submissions: 31 March 2022.

Special Issue Editor

Prof. Dr. Bonglee Kim
E-Mail Website
Guest Editor
Department of Pathology, College of Korean Medicine, Kyung Hee University, Seoul, Korea
Interests: oncology; epigenetics; miRNA; natural products; phytomedicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

MicroRNAs (miRNAs) are small noncoding RNAs about 18–24 nucleotides in length that have roles in cellular homeostasis functions in proliferation, cell cycle, development, differentiation, growth, and apoptosis. Various human diseases including multiple sclerosis, diabetes, nonalcoholic fatty liver disease, and cancer have been associated with deregulated miRNA expression. The aberrant expression of miRNAs is shown in various cancers. Recently, miRNAs have been identified as potential biomarkers for cancer diagnosis and response to therapy. However, the full mechanism of miRNA in cancer therapy is not still unknown. Several drugs including natural products have reported to have miRNA regulatory effect in cancer pathology including apoptosis, autophagy, drug resistance, invasion, metastasis, angiogenesis, etc.

In this Special Issue entitled “MicroRNAs in Cancer Therapy”, recent advances in miRNA studies in cancer therapy, including are of interest. 

Prof. Dr. Bonglee Kim
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • miRNA
  • cancer
  • apoptosis
  • proliferation
  • metastasis
  • resistance
  • chemotherapy
  • natural product
  • herbal medicine
  • plant extract
  • side effects of chemotherapy

Published Papers (1 paper)

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Research

Article
Impact of Oncogenic Targets by Tumor-Suppressive miR-139-5p and miR-139-3p Regulation in Head and Neck Squamous Cell Carcinoma
Int. J. Mol. Sci. 2021, 22(18), 9947; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22189947 - 14 Sep 2021
Viewed by 528
Abstract
We newly generated an RNA-sequencing-based microRNA (miRNA) expression signature of head and neck squamous cell carcinoma (HNSCC). Analysis of the signature revealed that both strands of some miRNAs, including miR-139-5p (the guide strand) and miR-139-3p (the passenger strand) of miR-139, were downregulated [...] Read more.
We newly generated an RNA-sequencing-based microRNA (miRNA) expression signature of head and neck squamous cell carcinoma (HNSCC). Analysis of the signature revealed that both strands of some miRNAs, including miR-139-5p (the guide strand) and miR-139-3p (the passenger strand) of miR-139, were downregulated in HNSCC tissues. Analysis of The Cancer Genome Atlas confirmed the low expression levels of miR-139 in HNSCC. Ectopic expression of these miRNAs attenuated the characteristics of cancer cell aggressiveness (e.g., cell proliferation, migration, and invasion). Our in silico analyses revealed a total of 28 putative targets regulated by pre-miR-139 (miR-139-5p and miR-139-3p) in HNSCC cells. Of these, the GNA12 (guanine nucleotide-binding protein subunit alpha-12) and OLR1 (oxidized low-density lipoprotein receptor 1) expression levels were identified as independent factors that predicted patient survival according to multivariate Cox regression analyses (p = 0.0018 and p = 0.0104, respectively). Direct regulation of GNA12 and OLR1 by miR-139-3p in HNSCC cells was confirmed through luciferase reporter assays. Moreover, overexpression of GNA12 and OLR1 was detected in clinical specimens of HNSCC through immunostaining. The involvement of miR-139-3p (the passenger strand) in the oncogenesis of HNSCC is a new concept in cancer biology. Our miRNA-based strategy will increase knowledge on the molecular pathogenesis of HNSCC. Full article
(This article belongs to the Special Issue MicroRNAs in Cancer Therapy)
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