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Metabolic Therapies for the Treatment of Cancer
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Metabolic Therapies for the Treatment of Cancer

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: closed (15 November 2022) | Viewed by 8323

Special Issue Editors

Dr. Adrienne C. Scheck

E-Mail Website
Guest Editor
Phoenix Children’s Hospital and the University of Arizona College of Medicine in Phoenix, Phoenix, AZ 85001, USA
Interests: brain tumors; metabolic therapies; adjuvant therapy; chemotherapy; radiation therapy; ketogenic diet; pediatric brain tumors; tumor metabolism; biomarkers of therapy
Dr. Angela M. Poff

E-Mail Website
Guest Editor
University of South Florida, Tampa, FL 33620, USA
Interests: cancer metabolism; warburg effect; metabolic therapy; ketogenic diet; complementary therapy; ketone metabolism; nutritional ketosis; brain cancer; neurological diseases

Special Issue Information

Dear Colleague

Metabolic alteration is a hallmark of cancer shared by virtually all tumor cells. In 1927 Otto Warburg demonstrated differences in glucose uptake and production of lactate between non-neoplastic and neoplastic cells. Tumor cells show a shift toward increased glycolytic flux in the cytosol and away from the tricarboxylic acid cycle and oxidative phosphorylation in the mitochondria. This occurs very early in tumorigenesis and allows for rapid cell proliferation even under conditions of hypoxia and in the presence of dysfunctional mitochondria.

While many early metabolic studies centered primarily on bioenergetics (particularly glucose and glutamine utilization), we now know that many other metabolic pathways are also reprogrammed in cancer, with all apparently inexorably intertwined with key components of tumor initiation, progression and therapy response.

This special issue will focus on pharmacologic and dietary therapies that target tumor metabolism to inhibit the growth of tumor cells and/or enhance the efficacy of currently available cytotoxic and immune therapies. Authors are invited to submit original research and review articles describing translational, preclinical and clinical studies relating to their efficacy and mechanisms of action when used alone or in combination with standard therapies.

Dr. Adrienne C. Scheck
Dr. Angela M. Poff
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

metabolic therapies; cancer treatment; pharmacologic and dietary; tumor metabolism; tumor cell; metabolism; metabolic pathways; therapy; complementary therapy; ketones ketogenic diet; dietary therapies; Warburg effect; aerobic glycolysis; deregulated cellular energetics

Published Papers (2 papers)

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Review

15 pages, 1090 KiB  
Review
Glioblastoma and Methionine Addiction
by Mark L. Sowers and Lawrence C. Sowers
Int. J. Mol. Sci. 2022, 23(13), 7156; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms23137156 - 28 Jun 2022
Cited by 4 | Viewed by 2596
Abstract
Glioblastoma is a fatal brain tumor with a bleak prognosis. The use of chemotherapy, primarily the alkylating agent temozolomide, coupled with radiation and surgical resection, has provided some benefit. Despite this multipronged approach, average patient survival rarely extends beyond 18 months. Challenges to [...] Read more.
Glioblastoma is a fatal brain tumor with a bleak prognosis. The use of chemotherapy, primarily the alkylating agent temozolomide, coupled with radiation and surgical resection, has provided some benefit. Despite this multipronged approach, average patient survival rarely extends beyond 18 months. Challenges to glioblastoma treatment include the identification of functional pharmacologic targets as well as identifying drugs that can cross the blood-brain barrier. To address these challenges, current research efforts are examining metabolic differences between normal and tumor cells that could be targeted. Among the metabolic differences examined to date, the apparent addiction to exogenous methionine by glioblastoma tumors is a critical factor that is not well understood and may serve as an effective therapeutic target. Others have proposed this property could be exploited by methionine dietary restriction or other approaches to reduce methionine availability. However, methionine links the tumor microenvironment with cell metabolism, epigenetic regulation, and even mitosis. Therefore methionine depletion could result in complex and potentially undesirable responses, such as aneuploidy and the aberrant expression of genes that drive tumor progression. If methionine manipulation is to be a therapeutic strategy for glioblastoma patients, it is essential that we enhance our understanding of the role of methionine in the tumor microenvironment. Full article
(This article belongs to the Special Issue Metabolic Therapies for the Treatment of Cancer)
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39 pages, 2857 KiB  
Review
Targeting Energy Metabolism in Cancer Treatment
by Joanna Kubik, Ewelina Humeniuk, Grzegorz Adamczuk, Barbara Madej-Czerwonka and Agnieszka Korga-Plewko
Int. J. Mol. Sci. 2022, 23(10), 5572; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms23105572 - 16 May 2022
Cited by 5 | Viewed by 4492
Abstract
Cancer is the second most common cause of death worldwide after cardiovascular diseases. The development of molecular and biochemical techniques has expanded the knowledge of changes occurring in specific metabolic pathways of cancer cells. Increased aerobic glycolysis, the promotion of anaplerotic responses, and [...] Read more.
Cancer is the second most common cause of death worldwide after cardiovascular diseases. The development of molecular and biochemical techniques has expanded the knowledge of changes occurring in specific metabolic pathways of cancer cells. Increased aerobic glycolysis, the promotion of anaplerotic responses, and especially the dependence of cells on glutamine and fatty acid metabolism have become subjects of study. Despite many cancer treatment strategies, many patients with neoplastic diseases cannot be completely cured due to the development of resistance in cancer cells to currently used therapeutic approaches. It is now becoming a priority to develop new treatment strategies that are highly effective and have few side effects. In this review, we present the current knowledge of the enzymes involved in the different steps of glycolysis, the Krebs cycle, and the pentose phosphate pathway, and possible targeted therapies. The review also focuses on presenting the differences between cancer cells and normal cells in terms of metabolic phenotype. Knowledge of cancer cell metabolism is constantly evolving, and further research is needed to develop new strategies for anti-cancer therapies. Full article
(This article belongs to the Special Issue Metabolic Therapies for the Treatment of Cancer)
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