Special Issue "Metabolic Therapies for the Treatment of Cancer"
Deadline for manuscript submissions: 31 March 2022.
2. Arizona State University, Tempe, AZ 85287, USA
Interests: brain tumors; metabolic therapies; adjuvant therapy; chemotherapy; radiation therapy; ketogenic diet; pediatric brain tumors; tumor metabolism; biomarkers of therapy
Metabolic alteration is a hallmark of cancer shared by virtually all tumor cells. In 1927 Otto Warburg demonstrated differences in glucose uptake and production of lactate between non-neoplastic and neoplastic cells. Tumor cells show a shift toward increased glycolytic flux in the cytosol and away from the tricarboxylic acid cycle and oxidative phosphorylation in the mitochondria. This occurs very early in tumorigenesis and allows for rapid cell proliferation even under conditions of hypoxia and in the presence of dysfunctional mitochondria.
While many early metabolic studies centered primarily on bioenergetics (particularly glucose and glutamine utilization), we now know that many other metabolic pathways are also reprogrammed in cancer, with all apparently inexorably intertwined with key components of tumor initiation, progression and therapy response.
This special issue will focus on pharmacologic and dietary therapies that target tumor metabolism to inhibit the growth of tumor cells and/or enhance the efficacy of currently available cytotoxic and immune therapies. Authors are invited to submit original research and review articles describing translational, preclinical and clinical studies relating to their efficacy and mechanisms of action when used alone or in combination with standard therapies.
Dr. Adrienne C. Scheck
Dr. Angela M. Poff
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
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metabolic therapies; cancer treatment; pharmacologic and dietary; tumor metabolism; tumor cell; metabolism; metabolic pathways; therapy; complementary therapy; ketones ketogenic diet; dietary therapies; Warburg effect; aerobic glycolysis; deregulated cellular energetics