Special Issue "Molecular and Cellular Mechanisms of Action of Markers of Tissue Degeneration"
Deadline for manuscript submissions: 28 February 2021.
Mammalian tissue degeneration plays a major role either at the onset or in the early stages of many chronic diseases and insults to human health. A common feature of these threats to human health is that they initially develop slowly until tissue degeneration reaches an irreversible critical point. This critical point is currently associated with the activation of the proteases inducing cell death by apoptosis, necrosis or lysosomal dysfunction (including autophagocytosis).
Studies of the molecular mechanisms underlying the biological dysregulation at the early and yet reversible stage of mammalian tissue degeneration are providing relevant clues to the most relevant molecular events triggering entry into the irreversible stage. The current knowledge points out that this early stage is a complex and multifactorial process induced by endogenous factors or exposure to drugs or environmental toxins that in most cases produce tissue inflammation, sustained cellular oxidative stress, and bioenergetic and cellular signaling dysregulation. Thus, there is a need to evaluate the relative contribution of different putative molecular mechanisms of dysregulation in each particular case, as well as the temporal sequence of molecular events that can lead to entry into the irreversible stage of tissue degeneration. Therefore, research on these molecular mechanisms is providing the most relevant biomarkers and biological targets for early diagnosis of the disease and/or for the design of rational therapeutic approaches to slow down or attenuate the severity of the health damage.
It is the aim of this Special Issue to focus on recent advances in the molecular mechanisms of biological dysregulation in the early and yet reversible stage of mammalian tissue degeneration.
Prof. Dr. Carlos Gutierrez-Merino
Prof. Dr. Ana M. Mata
Manuscript Submission Information
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