Special Issue "Innate Immunity at the Feto-Maternal Interface: Physiological and Pathological Aspects"
Deadline for manuscript submissions: closed (30 September 2021).
2. Department Obstetrics, Gynecology, Neonatology and Intensive Care Units, IRCCS Burlo Garofolo, 34137 Trieste, Italy
Interests: reproductive medicine; reproductive immunology; endometriosis; ovarian cancer; endometrial cancer; proteomics; microbiome; COVID-19 and reproduction
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Interests: Immunology, Innate Immunity, Complement System, Reproductive Immunology, Tumor Immunology, Mesothelioma, Inflammation, Endothelium
Interests: Reproductive Immunology, Inflammation, Complement System, Placenta Development, In vitro Models, Tumor Microenvironment, Endothelial Cells
The feto-maternal interface is still considered an enigmatic district from the immunological point of view, due to the complex biological mechanisms that have not yet been fully elucidated, such as the capability to create a tolerant environment towards the non-self embryonic antigens, but acting simultaneously as a barrier capable of defending the fetus from the attack of pathogens.
Currently, the study of the immune system at the uterine and placental levels is assuming greater interest for several reasons, such as the increased use of medically assisted procreation techniques; in particular, those involving oocyte donation; the augmentation of the incidence of pregnancy pathologies connected to the older maternal age; the high number of recurrent spontaneous abortions, especially related to recurrent implantation failure after IVF, and, finally, numerous and discordant literature that is emerging on the effects of SARS-Cov-2 in pregnancy.
This Special Issue aims to shed light on these unclear mechanisms that are crucial for the development of novel diagnostic tools and innovative therapeutic approaches.
Prof. Dr. Giuseppe Ricci
Prof. Roberta Bulla
Dr. Chiara Agostinis
Manuscript Submission Information
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- innate immunity
- complement system
- embryo-endometrial crosstalk
- embryo implantation
- implantation failure after IVF
- oocyte donation
- recurrent abortion