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Special Issue "Innate Immunity at the Feto-Maternal Interface: Physiological and Pathological Aspects"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: closed (30 September 2021).

Special Issue Editors

Prof. Dr. Giuseppe Ricci
E-Mail Website
Guest Editor
1. Department of Medicine, Surgery and Health Sciences, University of Trieste, 34137 Trieste, Italy
2. Department Obstetrics, Gynecology, Neonatology and Intensive Care Units, IRCCS Burlo Garofolo, 34137 Trieste, Italy
Interests: reproductive medicine; reproductive immunology; endometriosis; ovarian cancer; endometrial cancer; proteomics; microbiome; COVID-19 and reproduction
Special Issues and Collections in MDPI journals
Prof. Roberta Bulla
E-Mail Website
Guest Editor
Department of Life Sciences, University of Trieste, 34127 Trieste, Italy
Interests: Immunology, Innate Immunity, Complement System, Reproductive Immunology, Tumor Immunology, Mesothelioma, Inflammation, Endothelium
Dr. Chiara Agostinis
Guest Editor
Institute for Maternal and Child Health, IRCCS Burlo Garofolo, 34137 Trieste, Italy
Interests: Reproductive Immunology, Inflammation, Complement System, Placenta Development, In vitro Models, Tumor Microenvironment, Endothelial Cells

Special Issue Information

Dear Colleagues,

The feto-maternal interface is still considered an enigmatic district from the immunological point of view, due to the complex biological mechanisms that have not yet been fully elucidated, such as the capability to create a tolerant environment towards the non-self embryonic antigens, but acting simultaneously as a barrier capable of defending the fetus from the attack of pathogens.

Currently, the study of the immune system at the uterine and placental levels is assuming greater interest for several reasons, such as the increased use of medically assisted procreation techniques; in particular, those involving oocyte donation; the augmentation of the incidence of pregnancy pathologies connected to the older maternal age; the high number of recurrent spontaneous abortions, especially related to recurrent implantation failure after IVF, and, finally, numerous and discordant literature that is emerging on the effects of SARS-Cov-2 in pregnancy. 

This Special Issue aims to shed light on these unclear mechanisms that are crucial for the development of novel diagnostic tools and innovative therapeutic approaches.

Prof. Dr. Giuseppe Ricci
Prof. Roberta Bulla
Dr. Chiara Agostinis
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • innate immunity
  • complement system
  • embryo-endometrial crosstalk
  • embryo implantation
  • implantation failure after IVF
  • oocyte donation
  • recurrent abortion
  • pregnancy
  • pre-eclampsia
  • SARS-CoV-2

Published Papers

There is no accepted submissions to this special issue at this moment.
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