ijms-logo

Journal Browser

Journal Browser

Metabolic Bone Diseases: Molecular Biology, Pathophysiology and Therapy 2.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: closed (31 August 2021) | Viewed by 2604

Special Issue Editor

Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy
Interests: osteoporosis; metabolic bone diseases; hypovitaminosis D-related disorders; rare bone diseases; metabolic link between atherosclerosis and bone metabolism
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Identification of the mechanisms underlying the pathophysiology and therapies of metabolic bone diseases continues to be an area of significant research, attracting scientists from a variety of different fields. The discovery of the Wnt signal and the OPG/Rankl system has contributed significantly to the design and development of new drugs and molecules for the treatment of osteoporosis and other metabolic bone diseases.

For this Special Issue, we invite authors to submit manuscript research and review papers targeting the gamut of methodological and scientific innovation in this field. Of specific interest are papers focused on the discovery of novel drug targets, signaling pathways, and mechanisms of action relevant to metabolic bone diseases. These contributions can involve basic science and translational research or be highly focused on research models related to specific conditions like drug-induced bone loss or other secondary forms of osteoporosis or rare metabolic bone diseases.

Dr. Agostino Gaudio
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bone metabolism
  • Wnt signaling
  • OPG/Rankl system
  • osteoblast
  • osteoclast
  • osteoporosis

Related Special Issue

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

12 pages, 2683 KiB  
Article
Role of the Endocannabinoid/Endovanilloid System in the Modulation of Osteoclast Activity in Paget’s Disease of Bone
by Marco Paoletta, Antimo Moretti, Sara Liguori, Alessandra Di Paola, Chiara Tortora, Maura Argenziano, Francesca Rossi and Giovanni Iolascon
Int. J. Mol. Sci. 2021, 22(18), 10158; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms221810158 - 21 Sep 2021
Cited by 3 | Viewed by 2225
Abstract
The role of the endocannabinoid/endovanilloid (EC/EV) system in bone metabolism has recently received attention. Current literature evidences the modulation of osteoclasts and osteoblasts through the activation or inhibition of cannabinoid receptors in various pathological conditions with secondary involvement of bone tissue. However, this [...] Read more.
The role of the endocannabinoid/endovanilloid (EC/EV) system in bone metabolism has recently received attention. Current literature evidences the modulation of osteoclasts and osteoblasts through the activation or inhibition of cannabinoid receptors in various pathological conditions with secondary involvement of bone tissue. However, this role is still unclear in primary bone diseases. Paget’s disease of the bone (PDB) could be considered a disease model for analyzing the role of the EC/EV system on osteoclasts (OCs), speculating the potential use of specific agents targeting this system for managing metabolic bone disorders. The aim of the study is to analyze OCs expression of EC/EV system in patients with PDB and to compare OCs activity between this population and healthy people. Finally, we investigate whether specific agents targeting EC/EV systems are able to modulate OCs activity in this metabolic bone disorder. We found a significant increase in cannabinoid receptor type 2 (CB2) protein expression in patients with PDB, compared to healthy controls. Moreover, we found a significant reduction in multi-nucleated tartrate-resistant acid phosphatase (TRAP)–positive OCs and resorption areas after treatment with JWH-133. CB2 could be a molecular target for reducing the activity of OCs in PDB, opening new therapeutic scenarios for the management of this condition. Full article
Show Figures

Figure 1

Back to TopTop