Special Issue "Mechanisms of ER Protein Import"
Deadline for manuscript submissions: 30 September 2021.
Interests: human endoplasmic reticulum; protein import into the ER; calcium leakage from the ER; ATP/ADP exchange; molecular chaperones of the ER; Sec61 channel gating; Sec61-channelopathies; chaperonopathies
Interests: ATP transport; calcium homeostasis; calcium leakage; endoplasmic reticulum; membrane proteins; protein-protein interactions; protein targeting; protein transport; Sec61-channelopathies; Sec61 complex
Protein import into the endoplasmic reticulum (ER) is the first step in the biogenesis of approximately 10,000 different soluble and membrane proteins of mammalian cells, which amounts to about 30% of the proteome. All these proteins fulfill their functions either in the membrane or lumen of the ER itself, in one of the organelles of the pathways for endo- and exocytosis, or at the cell surface as plasma membrane or secreted proteins. ER protein import involves two stages—ER targeting, which guarantees membrane specificity, and the insertion of nascent membrane proteins into or translocation of soluble precursor polypeptides across the ER membrane. Typically, both processes depend on amino-terminal signal peptides or transmembrane helices. However, the targeting reaction may also involve the ER targeting of specific mRNAs. In addition, both processes may occur co- or post-translationally and are facilitated by various sophisticated machineries, which reside in the cytosol and the ER membrane, respectively. Except for resident ER proteins, proteins are delivered to their functional locations by vesicular transport. In this Special Issue, international experts in this area of cell biology report on their structural and mechanistic insights into various aspects of targeting, insertion, and translocation machineries, such as the signal recognition particle (SRP), its corresponding receptor, and the Sec61 complex. Furthermore, small-molecule inhibitors and toxins that interfere with ER protein import will be discussed in detail. With the last topic, this Special Issue provides a timely glimpse of how scientific analyses of ER protein import can contribute to the development of future therapeutic strategies against viruses, including SARS-CoV-2.
Prof. Dr. Richard Zimmermann
Dr. Sven Lang
Manuscript Submission Information
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- Protein targeting to the ER
- Insertion of proteins into the ER membrane
- Translocation of proteins into the ER
- Signal peptides
- Transmembrane helices
- Intrinsically disordered domains
- Sec61 complex
- Sec61 translocon
- TRAP complex
- Signal peptidase
- Sec61 channel inhibitors