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Special Issue "Recent Advances in Mesenchymal Stem Cell Immunomodulation and Regenerative Medicine 3.0"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 28 February 2022.

Special Issue Editor

Dr. Andrea Del Fattore
E-Mail Website
Guest Editor
Bone Physiopathology Group, Multifactorial Disease and Complex Phenotype Research Area, Bambino Gesù Children’s Hospital, 00146 Rome, Italy
Interests: bone cell biology; bone diseases; bone regeneration; mesenchymal stem cells; osteoclasts; osteoblasts; osteocytes; extracellular vesicles
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The landscape of therapeutic applications based on mesenchymal stem cells is continuously increasing due to their well-established abilities to modulate immune responses and to promote the regeneration of injured tissues. MSC, like several other cell types, exert many of their effects via paracrine signalling, including the release of extracellular vesicles (exosomes and microvesicles).

Numerous studies have already demonstrated the beneficial uses of MSC in both preclinical research and clinical trials. Efficacy was reported in the treatment of several animal models of inflammatory and autoimmune diseases and, in clinical settings, for the management of disorders such as GVHD, systemic lupus erythematosus, multiple sclerosis, and inflammatory bowel disease.

The purpose of this Special Issue is to bring together research/review articles on the recent advances in mesenchymal stem cells in the treatment of immune disorders and to provide a concise overview of MSC-based cell therapy in tissue regeneration. Articles on the effects of MSC-released extracellular vesicles are particularly welcome.

Dr. Andrea Del Fattore
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Mesenchymal stem cells
  • Immunomodulation
  • Regenerative medicine
  • Extracellular vesicles

Published Papers

This special issue is now open for submission.
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