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Special Issue "Bioactives and Nutraceuticals in Metabolic Syndrome 2021"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 31 July 2021.

Special Issue Editors

Dr. Enrique Barrajon
E-Mail Website
Guest Editor
Institute of Research, Development and Innovation in Healthcare Biotechnology of Elche (IDiBE), Miguel Hernández University (UMH), Alicante, Spain
Interests: natural compounds; polyphenols; marine compounds; cancer; antimicrobial; skin; cosmetics
Special Issues and Collections in MDPI journals
Prof. Dr. David Arráez-Román
E-Mail Website1 Website2
Guest Editor
1. Department of Analytical Chemistry, Faculty of Sciences, University of Granada, Avda Fuentenueva s/n, 18071 Granada, Spain
2. Research and Development of Functional Food Centre (CIDAF), Health Science Technological Park (PTS) Granada, Avda. del Conocimiento s/n, EdificioBioregión, 18007 Granada, Spain
Interests: bioactive phenolic compounds; metabolomics; analytical techniques; extraction processes; plant and food analysis; bioavailability
Special Issues and Collections in MDPI journals
Prof. Dr. María Herranz-López
E-Mail Website
Guest Editor
Instituto de Investigación, Desarrollo e Innovación en Biotecnologia Sanitaria at Miguel Hernández University, Elche, Spain
Interests: metabolic disorders; inflammation; bioactive compounds; cancer; cell death
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Metabolic syndrome is a group of metabolic abnormalities, such as insulin resistance, hypertension, dyslipidemia, and excess body fat around the waist that may occur in the same individual. This condition has a remarkable impact on health, leading to shortened life expectancy, and also an increase in the risk of heart diseases. Adults with metabolic syndrome present obesity-associated metabolic, oxidative and inflammatory disturbances. A better understanding of disease-associated metabolic pathway alterations may lead to the identification of new drugs and to the development of new therapies against metabolic abnormalities.

Natural products are a source of anti-inflammatory, antihypertensive, antioxidant, antithrombotic and antihyperglycaemic molecules, possibly useful in the treatment or prevention of metabolic disorders. These compounds could interact in humans with pleiotropic effects in a variety of tissues involved in stress response pathways, thus increasing the ingestion of dietary natural products could be helpful in the management of obesity-related deseases.

This Special Issue is a collection of research and review articles on the benefits of bioactives and nutraceuticals with a special interest in the “New Insights in Natural Compounds in the Management of the Metabolic Syndrome”.

As Guest Editors of this Special Issue, We cordially invite researchers from all around the world to contribute to this Special Issue by submitting original research articles, long and mini review papers, short notes, and opinions according to their expertise.

Dr. Enrique Barrajon
Prof. Dr. David Arráez-Román
Prof. María Herranz-López
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • metabolic disorders
  • metabolic pathways
  • bioactives and nutraceuticals
  • obesity
  • AMPK
  • anti-inflammatory
  • antihypertensive
  • antioxidant
  • metabolomics

Published Papers (1 paper)

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Open AccessArticle
Osthol Ameliorates Kidney Damage and Metabolic Syndrome Induced by a High-Fat/High-Sugar Diet
Int. J. Mol. Sci. 2021, 22(5), 2431; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22052431 - 28 Feb 2021
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Excessive intake of fructose results in metabolic syndrome (MS) and kidney damage, partly mediated by its metabolism by fructokinase-C or ketohexokinase-C (KHK-C). Osthol has antioxidant properties, is capable of regulating adipogenesis, and inhibits KHK-C activity. Here, we examined the potential protective role of [...] Read more.
Excessive intake of fructose results in metabolic syndrome (MS) and kidney damage, partly mediated by its metabolism by fructokinase-C or ketohexokinase-C (KHK-C). Osthol has antioxidant properties, is capable of regulating adipogenesis, and inhibits KHK-C activity. Here, we examined the potential protective role of osthol in the development of kidney disease induced by a Western (high-fat/high-sugar) diet. Control rats fed with a high-fat/high-sugar diet were compared with two groups that also received two different doses of osthol (30 mg/kg/d or 40 mg/kg/d body weight BW). A fourth group served as a normal control and received regular chow. At the end of the follow-up, kidney function, metabolic markers, oxidative stress, and lipogenic enzymes were evaluated. The Western diet induced MS (hypertension, hyperglycemia, hypertriglyceridemia, obesity, hyperuricemia), a fall in the glomerular filtration rate, renal tubular damage, and increased oxidative stress in the kidney cortex, with increased expression of lipogenic enzymes and increased kidney KHK expression. Osthol treatment prevented the development of MS and ameliorated kidney damage by inhibiting KHK activity, preventing oxidative stress via nuclear factor erythroid 2-related factor (Nrf2) activation, and reducing renal lipotoxicity. These data suggest that the nutraceutical osthol might be an ancillary therapy to slow the progression of MS and kidney damage induced by a Western diet. Full article
(This article belongs to the Special Issue Bioactives and Nutraceuticals in Metabolic Syndrome 2021)
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