Special Issue "Metabolism and Leukemia: From Biology to Therapies"
Deadline for manuscript submissions: 28 February 2021.
Interests: Acute Myeloid Leukemia; Acute Lymphoblastic Leukemia; Target therapy; Monoclonal Antibodies; Mastocytosis; Tyrosine Kinase Inhibitors
Altered metabolism plays a key role in malignancies, and has recently been defined as an emerging hallmark of cancer. This is true also in the setting of haematological neoplasms, including Acute Myeloid and Lymphoblastic Leukemias, which utilize altered metabolism to maximize cell growth and survival. In detail, many studies in literature demonstrated that, in order to maintain cell proliferation, expansion and survival, a reprogramming of metabolism must be performed to satisfy key bioenergetics, biosynthetic, and redox functions of leukemic cells. Furthermore, several metabolites have a signaling function and promote tumor growth and progression. The importance of metabolic adaptation for the survival of AML cells and the therapeutic potential of addressing different metabolic pathways have already been reported. As a consequence, starting from this rationale, in the last few years, several drugs have been developed to target specific metabolic pathways and enzymes, metabolites, and signaling pathways. Several studies, some of which are currently ongoing, have shown an acceptable safety profile of some of these metabolism-affecting drugs, even when used in combination with standard chemotherapy, which still represents the first line therapeutic option for fit AML and ALL patients. Nevertheless, in relapsed settings and in unfit/elderly populations, innovative therapeutic options are strongly required, and targeting metabolism may represent an attractive tool.
In this Special Issue, we're going to highlight the most recent data in the field, from biological setting to therapeutic implications.
Dr. Cristina Papayannidis
Manuscript Submission Information
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- Acute Myeloid Leukemia
- Acute Lymphoblastic Leukemia
- PI3K AKT