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Metal Ions in Cancer
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Metal Ions in Cancer

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: closed (31 March 2022) | Viewed by 5312

Special Issue Editor

Prof. Dr. Athanasios Salifoglou

E-Mail Website
Guest Editor
School of Chemical Engineering, Faculty of Engineering, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
Interests: bioinorganic chemistry; molecular engineering; hybrid materials; metallodrugs; cell (patho)physiologies; neurodegeneration; neoplastic process
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Metal ions are variably encountered in the biosphere of the planet, with key roles in the (patho)physiology of lower and higher organisms. Their (bio)chemically established role  in human physiology has led to startling revelations about their influence on genetic and cellular processes, supporting the integrity and dynamic nature of multi-organ human  assembly. However, in the face of lingering or detrimental cellular aberrations, such as cancer, local as well as universal chemical events unfold, which require selective and specific diagnostic and therapeutic approaches.  In that respect, metal ions usher in new possibilities, with synthetic (bio)inorganic, (bio)chemical, biophysical, and molecular biological sciences and engineering, bringing forth new materials and applications “from Lab to Clinic” in various forms of biomolecular approaches. This Special Issue aspires to assemble scientific contributions from the above fields, aiming to a) merge existing experimental and theoretical results into concrete knowledge regarding cancer, and b) generate new impetus in the field of cancer diagnostics and therapeutics, with metal-centered drugs and processes leading science and molecular engineering into the dawn of a new era in metallodrug theranostics.

Prof. Dr. Athanasios Salifoglou
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Metal complexes
  • Diagnostics
  • Therapeutics
  • Chemistry and biology
  • Carcinogenesis

Published Papers (2 papers)

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Research

17 pages, 2669 KiB  
Article
Induced Zinc Loss Produces Heterogenous Biological Responses in Melanoma Cells
by Emil Rudolf and Kamil Rudolf
Int. J. Mol. Sci. 2022, 23(15), 8312; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms23158312 - 27 Jul 2022
Cited by 1 | Viewed by 1660
Abstract
Zinc levels in serum and/or tissue are reported to be altered in melanoma with unknown effects on melanoma development and biology. The purpose of this study was to examine the effects of acute chelation of free intracellular zinc pools in melanoma cell lines [...] Read more.
Zinc levels in serum and/or tissue are reported to be altered in melanoma with unknown effects on melanoma development and biology. The purpose of this study was to examine the effects of acute chelation of free intracellular zinc pools in melanoma cell lines Bowes and A375, as well as selected melanoma tissue explants with high or low intracellular free zinc. Zinc chelating agent TPEN at the concentration of 25 µM was employed during 48 h, which significantly reduced intracellular free zinc while decreasing melanoma cell proliferation, inducing G1/S arrest and cell damage leading to mitochondrial, caspase-dependent apoptosis. Chelation of free zinc was also associated with increased generation of superoxide in cell lines but not marked lysosomal membrane damage. Conversely, melanoma explant cultures mostly displayed time-dependent loss of lysosomal membrane integrity in the presence of slowly growing superoxide levels. Loss of free zinc-dependent p53 activity was similarly disparate in individual melanoma models. Surviving melanoma cells were arrested in the cell cycle, and varying proportions of them exhibited features characteristic of premature senescence, which increased in time despite zinc reloading. The present results show that melanoma cells with varying free zinc levels respond to its acute loss in a number of individual ways, reflecting activated mechanisms including oxidative stress, lysosomal damage, and p53 activity leading to heterogenous outcomes including cell death, transient, and/or permanent cell cycle arrest and premature senescence. Full article
(This article belongs to the Special Issue Metal Ions in Cancer)
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20 pages, 7358 KiB  
Article
Antitumor Activity against A549 Cancer Cells of Three Novel Complexes Supported by Coating with Silver Nanoparticles
by Agnieszka Czylkowska, Bartłomiej Rogalewicz, Małgorzata Szczesio, Anita Raducka, Katarzyna Gobis, Paweł Szymański, Kamila Czarnecka, Bruno Cury Camargo, Jacek Szczytko, Alexey Babich, Sergey Dubkov and Petr Lazarenko
Int. J. Mol. Sci. 2022, 23(6), 2980; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms23062980 - 10 Mar 2022
Cited by 3 | Viewed by 3121
Abstract
A novel biologically active organic ligand L (N’-benzylidenepyrazine-2-carbohydrazonamide) and its three coordination compounds have been synthesized and structurally described. Their physicochemical and biological properties have been thoroughly studied. Cu(II), Zn(II), and Cd(II) complexes have been analyzed by F-AAS spectrometry and elemental analysis. The [...] Read more.
A novel biologically active organic ligand L (N’-benzylidenepyrazine-2-carbohydrazonamide) and its three coordination compounds have been synthesized and structurally described. Their physicochemical and biological properties have been thoroughly studied. Cu(II), Zn(II), and Cd(II) complexes have been analyzed by F-AAS spectrometry and elemental analysis. The way of metal–ligand coordination was discussed based on FTIR spectroscopy and UV-VIS-NIR spectrophotometry. The thermal behavior of investigated compounds was studied in the temperature range 25–800 °C. All compounds are stable at room temperature. The complexes decompose in several stages. Magnetic studies revealed strong antiferromagnetic interaction. Their cytotoxic activity against A549 lung cancer cells have been studied with promising results. We have also investigated the biological effect of coating studied complexes with silver nanoparticles. The morphology of the surface was studied using SEM imaging. Full article
(This article belongs to the Special Issue Metal Ions in Cancer)
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