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Special Issue "Redox Active Metals in Neurodegenerative Diseases: Therapeutic Implications"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 30 June 2021.

Special Issue Editor

Prof. Dr. Grażyna Gromadzka
E-Mail Website
Guest Editor
Collegium Medicum, Faculty of Medicine, Cardinal Stefan Wyszynski University, Wóycickiego 1/3 Street, 01-938 Warsaw, Poland

Special Issue Information

Dear Colleagues,

Redox-active metals play an important role in regulating various cellular pathways important for normal brain function, participating in processes such as myelination, synthesis and release of neurotransmitters, protein turnover, synthesis of neurotrophic factors, antioxidant defense and many others. The metabolism of these metals is tightly regulated by homeostatic systems, including transmembrane proteins and metallopochaperones, which regulate their absorption, intracellular localization, or excretion. Abnormalities in metal homeostasis are closely related to the onset and progression of neurodegenerative diseases. The proposal was even formulated of developing Redox Neurology as an independent subgroup of Neurology. Metal ion imbalance can induce oxidative stress, promote neuroinflammation, overproduction of amyloid-β, cause tau hyperphosphorylation, as well as mitochondrial and autophagic dysfunctions, which may initiate or intensify the aggregation of pathological forms of proteins and impair synaptic functions; it may also disrupt the function of endoplasmic organelles, causing endoplasmic stress. Changes due to metal ion imbalance can also aggravate abnormal distribution and deposition of metal ions, which can lead to chronic neurodegeneration. In recent years, the influence of redox metals on neurodegenerative diseases has been intensively studied. Despite the advances in knowledge, it is still not clear in which diseases redox active metals play a major or secondary pathogenic role, how redox active metals move from vital functions to playing a key role in pathological processes; what pathogenic mechanisms are involved in tissue damage induced by redox active metals, what protective mechanisms are disturbed in disease states. More knowledge is needed about possible therapeutic intervention strategies to prevent / reduce the pathogenic process caused or exacerbated by redox active metals.

This special issue is dedicated to the latest advances in research into the role of redox active metals in neurodegeneration. The aim is to provide an in-depth understanding of the fundamental role of copper, iron, cadmium, manganese and lesser known trace reactive metals in neurodegenerative brain diseases, and to present the results of experimental and clinical studies on pharmacological interventions to reverse metallic abnormalities that could be useful in treating common neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and other conditions such as stroke, multiple sclerosis, and hereditary diseases. Proposals for new therapeutic approaches to prevent and / or restore neurological changes by targeting any target at any stage of redox-active metal induced or exacerbated processes are welcome.

Prof. Dr. Grażyna Gromadzka
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers

This special issue is now open for submission.
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