Dear Colleagues,

Cellular functions that need an optimal interaction of mitochondria with other cellular components (endoplasmic reticulum, lipid droplets, lysosomes, nuclei) are relevant to energy metabolism, calcium handling, biosynthesis, anaplerosis and cataplerosis, proteostasis, autophagy, and apoptosis.

For correct functioning and meeting cellular needs, mitochondria adapt at different levels, from reorganization of the oxidative phosphorylation system, mitochondrial dynamics, and mitophagy to posttranslational modifications, differential gene expression, and biogenesis. All these processes are regulated by feedback mechanisms via exchange of information to other cellular compartments (metabolites, calcium, reactive oxygen species, and cytochrome c). Thus, recently, mitochondria have also been viewed as signaling organelles involved in intracellular communication and organ-crosstalk through mitokines that could signal via endocrine actions. Mitochondria can, therefore, alter metabolite signaling and nutrient handling, thus favoring other events triggered by intermediate lipid species (such as diacylglycerols and ceramides), hypoxia, epigenetics, or unbalanced amino acid profile.

For these reasons, mitochondrial dysfunction is directly implicated in the etiology of most chronic degenerative diseases and aging.

This Special Issue is dedicated to a series of studies that improve and update our current knowledge in mitochondrial function and communication both at the cellular level and systemically.

Dr. Pablo M. García-Rovés
Guest Editor

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• mitochondrial function
• mitochondrial communication
• mitochondrial proteostasis
• anaplerosis
• cataplerosis
• mitophagy
• apoptosis
• mitochondria–lysosome crosstalk
• mitochondrial dynamics
• amino acid and lipid metabolism
• mitokines

• Mitochondrial Function and Communication in International Journal of Molecular Sciences (8 articles)