Special Issue "miRNAs in the Era of Personalized Medicine: From Biomarkers to Therapeutics"
Deadline for manuscript submissions: closed (30 April 2021).
2. Comprehensive Multidisciplinary Endometriosis Unit, Consorcio Hospital General Universitario de Valencia, Valencia, Spain. Av. Tres Cruces, 2. PC: 46014 Valencia, Spain
3. Department of Paediatrics, Obstetrics and Gynaecology, University of Valencia, Valencia, Spain. Av. Blasco Ibáñez, 15. PC: 46010, Valencia, Spain
Interests: endometriosis; gynecological oncology; laparoscopy; minimally invasive surgery; robotic surgery; biomarkers
Interests: endometriosis; gynecological oncology; miRNAs; epigenomics; biomarkers; translational research
Interests: endometriosis; gynecological oncology; microRNAs; stem cells; proteoglycans; extracellular matrix; inflammation
Special Issues and Collections in MDPI journals
Personalized medicine has become a new paradigm for the management of a wide variety of diseases. A decisive factor for its development has been represented by the molecular characterization of tumours, paving the way for the development of risk stratification algorithms, biomarker development and targeted therapies.
miRNAs have attracted a greater interest in the last years as for the characterization of tumour biology. These small non-coding RNAs with regulatory properties have been proven to be deregulated in several pathologies, from benign pathologies as endometriosis or cardiovascular diseases to distinct forms of solid and haematological malignancies. Since a single miRNA might impact in multiple signalling pathways, they might be involved into disease pathophysiology and also might become potential therapeutic targets. Far from the classical miRNA mimic or antimiR approach, new evidences are pointing to targeted DNA methylation of miRNA promoters as a potential therapeutic strategy. Additionally, the discovery of miRNAs in a myriad of human biofluids has paved the way for its implementation as biomarkers of disease.
This Special Issue aims to broad the knowledge about current advances in the field of miRNAs as mechanisms of disease, biomarkers and potential therapeutic targets.
Dr. Juan Gilabert-Estellés
Dr. Josep Marí-Alexandre
Dr. Martin Götte
Manuscript Submission Information
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- Personalized medicine