Special Issue "Microglia Heterogeneity and Its Relevance for Translational Research"
Deadline for manuscript submissions: 30 September 2021.
Interests: neuroinflammation; glial cells; myeloid cells; microglia; brain tumours; immuno-oncology; neurodegeneration; immunometabolism
Interests: microglia; myeloid cells; neuroinflammation; neurodegeneration; neuropsychiatry; regenerative medicine; stem cells
Interests: microglia; myeloid cells; neuroinflammation; remyelination; myelination; regenerative medicine; stem cells; oligodendrocyte
Microglia are essential for the development and function of the adult brain. Their ontogeny, together with the singular environment of the central nervous system (CNS), make microglia a rather unique population of immune effector cells. The exceptional properties of microglial cells during development, as well as in the adult CNS, such as their role in synaptic stripping or the remarkable capacity to scan the brain parenchyma and rapidly react to its perturbations, have emerged in the past. More recently, technological advances in molecular biology, imaging, and single-cell analyses have further provided fascinating insights into the dynamic changes and diversity of microglia in response to aging and brain diseases, revealing their potential as therapeutic targets.
This Special Issue aims to provide a comprehensive overview of our current understanding of the diversity of microglia spanning from brain regional heterogeneity under homeostasis to disease-associated microglia emerging with distinct transcriptional profiles reflecting specific activation states under pathological settings, including tumorigenic and degenerative processes. Thus, we welcome the submission of articles that cover, but are not limited to the role of microglia in inflammatory processes associated with brain diseases as well as strategies for patient stratification, diagnostics or treatment of CNS disorders based on dynamic molecular changes in microglia.
Dr. Alessandro Michelucci
Prof. Dr. Josef Priller
Dr. Veronique Miron
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Brain tumours
- Translational medicine
- Precision medicine