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Special Issue "Mitochondria-Targeted Approaches in Health and Disease 2.0"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 31 August 2021.

Special Issue Editor

Prof. Dr. Dmitry Zorov
E-Mail Website1 Website2
Guest Editor
Department of Functional Biochemistry of Biopolymers, A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia
Interests: mitochondria; reactive oxygen species; oxidative stress; aging; ischemia; inflammation
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Special Issue Information

Dear Colleagues,

Mitochondria are one of the most intriguing intracellular elements. Apart from their great contribution to cellular bioenergetics, they perform various unique functions (both synthetic and regulatory). Now, it has become clear that mitochondrial fitness is a prerequisite of a healthy cell. Inherited or acquired mitochondrial dysfunction caused by changes in the genetic, lepidic, and proteinaceous content causing abnormal changes in structure and functions can be detrimental or even fatal for a cell. The intrinsic mechanism of mitochondrial quality control realizes the detection of unfit mitochondria or their elements with their elimination from the cell, ultimately clearing the system of abnormal mitochondrial structures. However, because of intrinsic and extrinsic challenges, this machinery misses mitochondrial defects, yielding the co-existence of normal and abnormal mitochondria within a single cell, which is a main index of diseases and aging. To avoid the unnecessary appearance of an unhealthy mitochondrial population in the cell when intrinsic mechanisms of reparation have partially or completely failed, various approaches have been successfully developed. The goal of the proposed Special Issue, Mitochondria-Targeted Approaches in Health and Disease, is to collect all of the possible methods of intervention into mitochondrial functioning, so as to prevent or repair unwanted changes in mitochondrial structure and function.

Prof. Dr. Dmitry Zorov
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • mitochondrial
  • membrane potential
  • DNA
  • ATP synthase
  • quality control
  • mitophagy
  • diseases
  • targeting
  • population analysis
  • death
  • cells
  • signaling
  • reactive oxygen species
  • radicals
  • damage
  • protection
  • structure
  • functions
  • respiratory chain
  • complexes

Related Special Issue

Published Papers

This special issue is now open for submission.
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