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Special Issue "Molecular Mechanisms of Muscle Fatigue"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: 15 October 2021.

Special Issue Editor

Dr. Dumitru Constantin-Teodosiu
E-Mail Website
Guest Editor
MRC/Arthritis Research UK Centre for Musculoskeletal Ageing Research, Division of Physiology, Pharmacology and Neuroscience, University of Nottingham, Nottingham, UK
Interests: type 2 diabetes; muscle insulin resistance; sepsis; inflammation; energy metabolism; ageing; inactivity

Special Issue Information

Dear Colleagues,

Large parts of the global population have recently been exposed to the still unabated COVID-19 coronavirus. While the percentage of people recovering from virus exposure without significant ill-health symptoms or side effects is fortunately high, However, some survivors (10%) experience a syndrome that includes long-term debilitating extreme tiredness (fatigue), pulmonary (shortness of breath, chest pain or tightness), and mental difficulties.

The prime sites of fatigue seem to be within the muscle cell itself and, for the most part, do not implicate the central nervous system or the neuromuscular junction. The British NICE guideline scope (October 2020) defines post-COVID syndrome as signs consistent with symptoms that develop during or following an infection. This condition is well known to be positively associated with muscle wasting.

Muscle atrophy can also occur after long periods of inactivity in association with poor nutrition. When muscle wasting occurs, muscles become less bulky and floppier. Each muscle fibre is just as strong, but there are not so many of them so, collectively, they do not contract as effectively. This easily leads to exhaustion when one tries to do things that would have been easier when the muscles were fit. Fortunately, with regular controlled exercise regimes, pharmacological intervention, and sensible dieting, the condition is reversible even with increasing age, albeit to a lower degree than for younger generations.

By validating the recognized inflammation/infection-related molecular mechanisms underlying muscle fatigue/waste, one could then apply sensible pharmacological, physiological (e.g., targeted exercise regimen) or nutritional interventions aimed at increasing muscle mass and regaining of muscle strength. This special issue welcomes both original research articles and comprehensive reviews (4000+ words) related to the topic.

Dr. Dumitru Constantin-Teodosiu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • infection
  • inflammation
  • protein catabolism
  • muscle wasting
  • energy metabolism
  • muscle mass
  • muscle signalling pathway
  • muscle hypertrophy interventions

Published Papers

This special issue is now open for submission.
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