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The Role and Modulation of Inflammation in Diseases
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The Role and Modulation of Inflammation in Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: closed (31 August 2022) | Viewed by 5294

Special Issue Editor

Dr. Ľuba Hunáková

E-Mail Website
Guest Editor
Faculty of Medicine, Comenius University in Bratislava, Institute of Immunology, Odborárske nám 14, 813 72 Bratislava, Slovakia
Interests: cancer biology; cancer cell signalling; flow cytometry; cell culture; cancer immunology; inflammation; apoptosis; immunofluorescence; tumor microenvironment; neurobiology of cancer; survivorship
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

Inflammation is a common mechanism underlying many diseases, including cardiovascular, autoimmune, pulmonary, neurodegenerative diseases and cancer. However, the regulatory mechanisms  of inflammation are not completely understood. Various immune cells, cytokines, chemokines and other mediators, including non-immune mechanisms, play a great role in the development of inflammation.

In this Special Issue, the focus will be on the genetic, cellular, and molecular markers and regulatory mechanisms, such as neural, immune, endocrine and others, that contribute to the modulation of inflammation in various diseases. Identification of such markers and mechanisms can lead to the development of personalized diagnostic, prevention and treatment strategies.

Dr. Ľuba Hunáková
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • inflammation
  • inflammatory biomarkers
  • cytokines, chemokines
  • signal transduction
  • transcription control of inflammation
  • gut microbiota–immunity axis
  • psychoneuroimmunoendocrine axis
  • immunomodulation
  • exosomes
  • anti-inflammatory agents
  • oxidative stress-related inflammation
  • inflammation-related disorders

Published Papers (2 papers)

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Review

25 pages, 1335 KiB  
Review
Cross-Talk between the Cytokine IL-37 and Thyroid Hormones in Modulating Chronic Inflammation Associated with Target Organ Damage in Age-Related Metabolic and Vascular Conditions
by Ljiljana Trtica Majnarić, Zvonimir Bosnić, Mario Štefanić and Thomas Wittlinger
Int. J. Mol. Sci. 2022, 23(12), 6456; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms23126456 - 09 Jun 2022
Cited by 5 | Viewed by 2172
Abstract
Chronic inflammation is considered to be the main mechanism contributing to the development of age-related metabolic and vascular conditions. The phases of chronic inflammation that mediate the progression of target organ damage in these conditions are poorly known, however. In particular, there is [...] Read more.
Chronic inflammation is considered to be the main mechanism contributing to the development of age-related metabolic and vascular conditions. The phases of chronic inflammation that mediate the progression of target organ damage in these conditions are poorly known, however. In particular, there is a paucity of data on the link between chronic inflammation and metabolic disorders. Based on some of our own results and recent developments in our understanding of age-related inflammation as a whole-body response, we discuss the hypothesis that cross-talk between the cytokine IL-37 and thyroid hormones could be the key regulatory mechanism that justifies the metabolic effects of chronic tissue-related inflammation. The cytokine IL-37 is emerging as a strong natural suppressor of the chronic innate immune response. The effect of this cytokine has been identified in reversing metabolic costs of chronic inflammation. Thyroid hormones are known to regulate energy metabolism. There is a close link between thyroid function and inflammation in elderly individuals. Nonlinear associations between IL-37 and thyroid hormones, considered within the wider clinical context, can improve our understanding of the phases of chronic inflammation that are associated with target organ damage in age-related metabolic and vascular conditions. Full article
(This article belongs to the Special Issue The Role and Modulation of Inflammation in Diseases)
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14 pages, 6673 KiB  
Review
Vaccination against Atherosclerosis: Is It Real?
by Anastasia V. Poznyak, Evgeny E. Bezsonov, Tatyana V. Popkova, Antonina V. Starodubova and Alexander N. Orekhov
Int. J. Mol. Sci. 2022, 23(5), 2417; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms23052417 - 22 Feb 2022
Cited by 3 | Viewed by 2538
Abstract
Atherosclerosis has been known in medicine for several centuries. As early as 1755, the Swedish anatomist Albrecht von Haller used the term “atheroma” to describe vascular lesions. Atherosclerosis may originate from an unbalanced diet or bad habits, and is mainly found in developed [...] Read more.
Atherosclerosis has been known in medicine for several centuries. As early as 1755, the Swedish anatomist Albrecht von Haller used the term “atheroma” to describe vascular lesions. Atherosclerosis may originate from an unbalanced diet or bad habits, and is mainly found in developed countries. Clinical trials have been conducted to establish the causes of atherosclerosis, and also to develop treatments for this disease. However, prevention of the disease has always been better than treatment, so vaccination may be the key to saving thousands of lives. The creation of a vaccine may be directly related to the study of autoimmune processes occurring in the body, immunity. This review considers the issues related to the involvement of the immune response in the development of atherosclerotic lesions. Modern concepts of atherogenesis, immune inflammation in atherosclerosis, and potential vaccine targets are also discussed. There is a particular focus on experimental and clinical data supporting the development of immune therapies to reduce cardiovascular risk. Full article
(This article belongs to the Special Issue The Role and Modulation of Inflammation in Diseases)
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