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Special Issue "Molecular and Biological Mechanisms of Longevity"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 31 December 2021.

Special Issue Editor

Prof. Dr. Irmgard Tegeder
E-Mail Website
Guest Editor
Pharmazentrum Frankfurt, Dept. of Clinical Pharmacology, Goethe-University of Frankfurt, Theodor Stern Kai 7, Bd. 74, 4th Fl, 60590 Frankfurt am Main, Germany
Interests: nerve injury and neuropathic pain; pain and aging; central adaptations to chronic pain; multiple sclerosis; neuroinflammation; neuro-immunologic communication; redox signaling; nitric oxide; endocannabinoids and other lipid signaling molecules; progranulin; autophagy
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Longevity, in the sense of maintaining a long and healthy life, is influenced by genes and environmental factors. Particularly, modulation of the latter has gained recent interest for the prevention of disease and aging. The molecular and cell biological mechanisms that help to maintain a long and healthy life are not simply the opposite of aging, but characterized by a positive gain of resource-sparing functions such as change of enzyme activity, enhancement of cellular waste clearance, or adaptations to mild challenges, which increase the resilience towards major stressors. The maintenance of the cellular homeostasis of nutrients, metabolites, redox states, proteins, RNA molecules, etc. is a major challenge. It is particularly intriguing to unravel how for example intermittent undulations caused by physical and mental exercise, intermittent fasting, social events, or resetting of the internal clocks help to extend the individual’s life.

In the present Special Issue, we invite contributions addressing molecular and biological mechanisms of longevity, including all aspects from genetic, epigenetic, metabolic, endocrine, immune, or redox-mediated mechanisms to environmental factors such as nutrition, sleep, social life, or exercise. Original research papers and reviews are equally welcome, and may involve in vitro and in vivo studies in different cells and organisms. The Special Issue will emphasize common and specific mechanisms adopted by various organisms to maintain a long and healthy life and highlight translational aspects ranging from molecules to human life at old age.

Prof. Dr. Irmgard Tegeder
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Longevity
  • Lifespan
  • Health
  • Senescence
  • Homeostasis
  • Proteostasis
  • Nutrition
  • Redox balance
  • Metabolic balance

Published Papers

This special issue is now open for submission.
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