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Special Issue "Novel Insights into Molecular Biology of Urological Cancers"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: 31 March 2022.

Special Issue Editor

Prof. Dr. Giuseppe Lucarelli
E-Mail Website
Guest Editor
Department of Emergency and Organ Transplantation – Urology, Andrology and Kidney Transplantation Unit - University of Bari « Aldo Moro », 70124 Bari, Italy
Interests: renal cell carcinoma; prostate cancer; bladder cancer; metabolomics; biomarkers
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Kidney, prostate, and bladder cancers are among the ten leading tumor types for the new estimated cancer cases in males, according to the American Cancer Society.

In recent years, many studies have provided novel insights into the molecular mechanisms involved in urological tumor pathogenesis, leading to the identification of potential biomarkers for early diagnosis, risk assessment, and outcome prediction. Moreover, the introduction of high-throughput technologies has led to a greater understanding of the pathways underlying the development and progression of these tumors and the identification of novel potential therapeutic targets. This Special Issue of the International Journal of Molecular Sciences will be dedicated to the application of different omics approaches for understanding the perturbations of biological systems occurring in the pathogenesis of the genitourinary system.

Prof. Giuseppe Lucarelli
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • renal cell carcinoma
  • prostate cancer
  • bladder carcinoma
  • testicular tumors
  • omics
  • pathology

Published Papers (1 paper)

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Review

Review
LncRNAs in the Regulation of Genes and Signaling Pathways through miRNA-Mediated and Other Mechanisms in Clear Cell Renal Cell Carcinoma
Int. J. Mol. Sci. 2021, 22(20), 11193; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms222011193 - 17 Oct 2021
Viewed by 313
Abstract
The fundamental novelty in the pathogenesis of renal cell carcinoma (RCC) was discovered as a result of the recent identification of the role of long non-coding RNAs (lncRNAs). Here, we discuss several mechanisms for the dysregulation of the expression of protein-coding genes initiated [...] Read more.
The fundamental novelty in the pathogenesis of renal cell carcinoma (RCC) was discovered as a result of the recent identification of the role of long non-coding RNAs (lncRNAs). Here, we discuss several mechanisms for the dysregulation of the expression of protein-coding genes initiated by lncRNAs in the most common and aggressive type of kidney cancer—clear cell RCC (ccRCC). A model of competitive endogenous RNA (ceRNA) is considered, in which lncRNA acts on genes through the lncRNA/miRNA/mRNA axis. For the most studied oncogenic lncRNAs, such as HOTAIR, MALAT1, and TUG1, several regulatory axes were identified in ccRCC, demonstrating a number of sites for various miRNAs. Interestingly, the LINC00973/miR-7109/Siglec-15 axis represents a novel agent that can suppress the immune response in patients with ccRCC, serving as a valuable target in addition to the PD1/PD-L1 pathway. Other mechanisms of action of lncRNAs in ccRCC, involving direct binding with proteins, mRNAs, and genes/DNA, are also considered. Our review briefly highlights methods by which various mechanisms of action of lncRNAs were verified. We pay special attention to protein targets and signaling pathways with which lncRNAs are associated in ccRCC. Thus, these new data on the different mechanisms of lncRNA functioning provide a novel basis for understanding the pathogenesis of ccRCC and the identification of new prognostic markers and targets for therapy. Full article
(This article belongs to the Special Issue Novel Insights into Molecular Biology of Urological Cancers)
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