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Special Issue "Molecular Research of Nuclear Receptors and Oncology"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 30 April 2022.

Special Issue Editor

Prof. Dr. Kouichi Yoshinari
E-Mail Website
Guest Editor
Laboratory of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
Interests: nuclear receptors; Ah receptor; gene regulation; drug/xenobiotic metabolism; liver; hepatotoxicity; hepatocarcinogenesis

Special Issue Information

Dear Colleagues, 

Nuclear receptors are a group of transcription factors that respond to endogenous and xenobiotic compounds. They play numerous physiological, pathophysiological, and toxicological functions in humans, including the synthesis, homeostasis, and actions of hormones and vitamins, energy metabolism and xenobiotic metabolism and disposition, by directly (through DNA binding) or indirectly (through protein–protein interaction) regulating gene expression. In the field of oncology, sex hormone-responsive nuclear receptors, such as estrogen receptor and androgen receptor, have been targets of cancer chemotherapy. In fact, a number of drugs targeting these receptors have been developed and used clinically. Not only agonists and antagonists but also selective modulators of these receptors’ functions are used, although their mechanisms of action are not fully understood. Xenobiotic-responsive nuclear receptors, such as CAR and PXR, are also drawing the attention of researchers from the viewpoint of chemical carcinogenesis and the metabolism and pharmacokinetics/pharmacodynamics of chemotherapeutic agents. Moreover, several nuclear receptors, including RORγ and NR4A1, have been reported to modulate immunity and inflammation. Due to a close relation between cancer and immunity/inflammation, nuclear receptors may become a novel target of cancer therapy. This Special Issue welcomes original and review manuscripts describing recent progress in nuclear receptor research in oncology at molecular levels.

Prof. Dr. Kouichi Yoshinari
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • gene regulation
  • protein–protein interaction
  • carcinogenesis
  • hormone-sensitive cancer
  • cancer chemotherapy
  • tumor marker
  • cancer stem cell

Published Papers

This special issue is now open for submission.
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