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Special Issue "Multiple Myeloma: Focus on Molecular and Epigenetic Aspects"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: 20 November 2021.

Special Issue Editor

Prof. Dr. Bogusław Machaliński
E-Mail Website
Guest Editor
Department of General Pathology, Pomeranian Medical University in Szczecin, 70-111 Szczecin, Poland
Interests: stem cell-based adjuvant therapies; neurotrophic factors; angiogenesis; stem cell transplantation; regenerative medicine
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Special Issue Information

Dear Colleagues,

Multiple myeloma (MM) is a systemic disease caused by the multifocal proliferation of plasma cells capable of producing monoclonal, homogeneous immunoglobulins whose genes have been recombined or somatically hypermutated. The conversion of normal plasmocytes into an expansive myeloma clone occurs as a result of the disturbance of various processes, e.g., damage to the cytokine network, angiogenesis, chromosomal aberrations (e.g., monosomy 13 and 14q32 translocation) and genetic changes involving Ras/p53. The introduction of new drugs for the treatment of multiple myeloma was a significant breakthrough that improved prognosis and lengthened the average survival time of patients. However, significant molecular, including epigenetic, changes can affect both the pathogenesis of the disease and the patient’s response to treatment, leading to the development of resistance to or side effects from treatment such as peripheral neuropathy.

We therefore invite investigators to contribute original research as well as review articles that focus on efforts to understand and elucidate various aspects of advances in the molecular, including epigenetic, field of research underlying the pathobiology of multiple myeloma affecting the survival or proliferation of myeloma cells, responses to antimyeloma drugs, development of resistance and side effects of therapy.

Research in this area may bring us closer to understanding the pathophysiology of multiple myeloma, developing new effective therapies, and transforming myeloma into a curable disease.

Prof. Dr. Bogusław Machaliński
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers

This special issue is now open for submission.
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