Special Issue "Multiple Myeloma: Focus on Molecular and Epigenetic Aspects"
Deadline for manuscript submissions: 20 November 2021.
Interests: stem cell-based adjuvant therapies; neurotrophic factors; angiogenesis; stem cell transplantation; regenerative medicine
Special Issues and Collections in MDPI journals
Multiple myeloma (MM) is a systemic disease caused by the multifocal proliferation of plasma cells capable of producing monoclonal, homogeneous immunoglobulins whose genes have been recombined or somatically hypermutated. The conversion of normal plasmocytes into an expansive myeloma clone occurs as a result of the disturbance of various processes, e.g., damage to the cytokine network, angiogenesis, chromosomal aberrations (e.g., monosomy 13 and 14q32 translocation) and genetic changes involving Ras/p53. The introduction of new drugs for the treatment of multiple myeloma was a significant breakthrough that improved prognosis and lengthened the average survival time of patients. However, significant molecular, including epigenetic, changes can affect both the pathogenesis of the disease and the patient’s response to treatment, leading to the development of resistance to or side effects from treatment such as peripheral neuropathy.
We therefore invite investigators to contribute original research as well as review articles that focus on efforts to understand and elucidate various aspects of advances in the molecular, including epigenetic, field of research underlying the pathobiology of multiple myeloma affecting the survival or proliferation of myeloma cells, responses to antimyeloma drugs, development of resistance and side effects of therapy.
Research in this area may bring us closer to understanding the pathophysiology of multiple myeloma, developing new effective therapies, and transforming myeloma into a curable disease.
Prof. Dr. Bogusław Machaliński
Manuscript Submission Information
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