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Special Issue "Non-Coding RNAs in Human Neurodevelopmental Disorders and Brain Disorders"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 31 August 2021.

Special Issue Editors

Prof. Dr. Cristina Barbagallo
E-Mail Website
Guest Editor
Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy
Interests: non-coding RNAs; microRNAs; uveal melanoma; colorectal cancer; exosomes; liquid biopsy; biomarker discovery
Prof. Dr. Marco Ragusa
E-Mail Website
Guest Editor
Department of Biomedical and Biotechnological Sciences, Section of Biology and Genetics G. Sichel, University of Catania, via Santa Sofia 87, 95123, Catania, Italy
Interests: noncoding RNAs; expression analysis; cell biology; circulating RNAs; exosomes; uveal melanoma; colon cancer; glioblastoma
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Initially considered as splicing errors or transcripts originating from “junk DNA”, non-coding RNAs (ncRNAs) are now recognized as key actors of cellular physiology and pathology. The new millennium brought to light the existence of long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs). The results of the Human Genome Project published in 2001 showed that about 85-90% of our genome is transcribed in RNA, even though only proteins cover about 1.2% of the entire genome. Since this groundbreaking discovery, various articles have reported on lncRNAs and circRNAs, showing that these molecules play a crucial role in cells as epigenetic regulators of almost all biological processes, similar to already known microRNAs (miRNAs). Several studies have shown that ncRNAs are dysregulated in pathological tissues and body fluids, paving the way to their application in clinical practice as therapeutic targets and diagnostic/prognostic biomarkers. This new field of research also extends to neurodevelopmental disorders and brain disorders, where ncRNAs have been identified as potential contributors to pathogenesis. This Special Issue will describe the current knowledge on ncRNAs (including miRNAs, lncRNAs, and circRNAs) in the onset and progression of neurodevelopmental disorders and brain disorders. We welcome research articles and reviews on altered expression in tissues or body fluids, polymorphisms, or splicing variants of ncRNAs that are associated with specific disorders.


Prof. Dr. Cristina Barbagallo 
Prof. Dr. Marco Ragusa
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • non-coding RNAs
  • microRNAs
  • long non-coding RNAs
  • circular RNAs
  • neurodevelopment
  • biomarkers
  • polymorphisms

Published Papers

This special issue is now open for submission.
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