Special Issue "Non-Coding RNAs in Human Neurodevelopmental Disorders and Brain Disorders"
Deadline for manuscript submissions: 31 August 2021.
Interests: non-coding RNAs; microRNAs; uveal melanoma; colorectal cancer; exosomes; liquid biopsy; biomarker discovery
Interests: noncoding RNAs; expression analysis; cell biology; circulating RNAs; exosomes; uveal melanoma; colon cancer; glioblastoma
Special Issues and Collections in MDPI journals
Initially considered as splicing errors or transcripts originating from “junk DNA”, non-coding RNAs (ncRNAs) are now recognized as key actors of cellular physiology and pathology. The new millennium brought to light the existence of long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs). The results of the Human Genome Project published in 2001 showed that about 85-90% of our genome is transcribed in RNA, even though only proteins cover about 1.2% of the entire genome. Since this groundbreaking discovery, various articles have reported on lncRNAs and circRNAs, showing that these molecules play a crucial role in cells as epigenetic regulators of almost all biological processes, similar to already known microRNAs (miRNAs). Several studies have shown that ncRNAs are dysregulated in pathological tissues and body fluids, paving the way to their application in clinical practice as therapeutic targets and diagnostic/prognostic biomarkers. This new field of research also extends to neurodevelopmental disorders and brain disorders, where ncRNAs have been identified as potential contributors to pathogenesis. This Special Issue will describe the current knowledge on ncRNAs (including miRNAs, lncRNAs, and circRNAs) in the onset and progression of neurodevelopmental disorders and brain disorders. We welcome research articles and reviews on altered expression in tissues or body fluids, polymorphisms, or splicing variants of ncRNAs that are associated with specific disorders.
Prof. Dr. Cristina Barbagallo
Prof. Dr. Marco Ragusa
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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- non-coding RNAs
- long non-coding RNAs
- circular RNAs