Special Issue "Molecular Mechanisms of Neural Stem Cells (NSC) Development - Systems Approach"
Deadline for manuscript submissions: 31 December 2021.
Interests: cell biology; stem cells; genomics; development; neuroscience; systems biology
Interests: neural engineering; systems neuroscience
Stem cell technologies, including the generation of neural stem cells and 3D brain organoids, have opened an unprecedented path toward understanding neural development, pathologies, and their control at the new global systems levels. This has become feasible in the face of recent developments in systems science, including high-throughput genomics, proteomics, and electro-synaptomics, and nanophotonics engineering.
New studies indicate that intra- and inter-chromosomal DNA interactions determine global genome functions and thereby organismal development. Therefore, understanding the relationship between genome physical structure, function, and development of active neuronal networks, and their multilevel controls, is at the basis of transformative research.
A new generation of nanophotonic optogenomic devices, integrated opto-microelectrode-array hybrid platforms, and atomic force microscopy techniques, open the path toward analyzing, and controlling the development and functions of the 3D neuronal networks. These platforms, fortified by the artificial intelligence of powerful computers, will solve, model, and manipulate the genome and neuronal multi-network systems. This Special Issue will publish current studies and progress in all these areas and lay out a map for future studies that will ultimately lead to an integrated genome-neuronal function model constructed by correlating genomic topology, gene activity networks, protein networks, and the properties of the resultant neuronal networks.
Prof. Michal K. Stachowiak
Dr. Anirban Dutta
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
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- Stem cells
- Genome topology
- Gene activity networks
- Genes for mitochondrial proteins
- Cerebral organoids
- Neural development
- Brain surface tension
- High-density microelectrode arrays (HDMEA)
- 3D neuronal networks
- Artificial intelligence