Special Issue "Neuroinflammation and Cell Death: What Is New?"
Deadline for manuscript submissions: 31 July 2021.
Interests: cerebral ischemia; in vivo and in vitro models; Parkinson's disease; calcium homeostasis; mitochondria; neruonal metabolism; astrocytes; microglia; mitophagy; apoptosis; neurodegeneration; neuroinflammation; sodium calcium exchangers; transporters; calcium channels
Special Issues and Collections in MDPI journals
Neuroinflammation plays a key pathogenetic role in a broad range of neurological and neurodegenerative disorders including multiple sclerosis, stroke, neoplasia, Parkinson’s Disease, Alzheimer’s Disease, and traumatic brain injury. Neuroinflammation is indeed emerging as an important clue in the pathophysiology of several neurodegenerative disorders for the development of disease-modifying treatments and therefore, potentially able to countreact this process. However, whether the neuroinflammatory processes are a cause or a consequence of neuronal degeneration still remains an unanswered question. The activation of brain glial cells, principally microglia and astrocytes represents a critical feature of neuroinflammation mainly related to the release various soluble factors that can accelerate the rate of neurodegeneration, the synaptic loss, and the synaptic dysfunction associated to neurological disorderd. On the other hand, there is evidence that activated microglia might also have neuroprotective effects in these pathological conditions.
This Special Issue of IJMS aims to provide a comprehensive synopsis of the state-of-the-art of neuroinflammation research from cellular to molecular mechanisms in order to delve deeper into the unresolved questions with a special focus on the relationship between markers of neuroinflammation and clinical indices of neurodegeneration, the causal relationship between these two phenomena, and the identification of biomarkers capable of measuring neuroinflammation in vivo, as well as of tracking its course over time, for prognosis and monitoring of effects of disease-modifying therapies.
You are warmly invited to submit original research and review articles related to any of these aspects.
Dr. Antonella Scorziello
Dr. Maria José Sisalli
Manuscript Submission Information
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- neurodegenerative disorders
- neuronal death
- cellular homeostasis
- calcium homeostasis
- oxidative stress
- microglial cells
- magnetic resonance imaging
- Parkinson’s disease
- Alzheimer’s disease
- multiple sclerosis
- traumatic brain injury
- metabolic dysfunction
- diagnostic and therapeutical approaches