Special Issue "Epigenetic Alterations in Neuromuscular Disorders"
Deadline for manuscript submissions: closed (31 January 2021).
We now know that skeletal muscle can be programmed early in life and memorize exposure to environmental stimuli such as exercise, nutriments, and probably many other cues. Furthermore, skeletal muscle differentiation involves complex interplays and coordinated action of stage-specific transcription factors able to orchestrate the different steps of this differentiation from the proliferation of stem cells to the formation of mature multinucleated muscle fibers. Understanding the precise regulation of pathways at play during skeletal muscle differentiation and mechanisms that underpin such cellular specification is, therefore, important for deciphering normal muscle function and also detrimental alterations associated with physiological or pathological aging and a number of rare to common diseases.
Epigenetic regulation, including DNA methylation changes, histone post-translational modifications, and micro RNAs are crucial for controlling gene expression through recruitment of various chromatin-modifying enzymes that drive chromatin dynamics during myogenesis. Epigenetic pathways involved in the control of gene activity and expression, which are not dependent on the genetic DNA code, thus, emerge as important modulators of muscle cells function, muscle mass, adaptation throughout life, and diseases.
The goal of this series of articles focuses on neuromuscular disorders epigenetics is to cover the current view on the subject in skeletal muscle differentiation but also to illustrate how the epigenetic-dependent translation of environmental cues contribute to frailty and loss of muscle mass, in particular during aging or in a number of diseases.
Dr. Frederique Magdinier
Manuscript Submission Information
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- satellite cells
- stem cells
- myogenic factors
- neuromuscular junctions
- DNA methylation
- repetitive DNA sequences
- nuclear topology
- neuromuscular disorders