Special Issue "Neurotoxic Effects of Animal Venoms: Molecular Mechanisms and Prevention"
Deadline for manuscript submissions: 31 December 2021.
In the process of evolution, some animals have developed the ability to produce venoms for defense and hunting. In hunting, the main task of the venom is to efficiently immobilize prey. The easiest way to do this is by disrupting the function of the nervous system. Therefore, the nervous system is one of the main targets for venoms. Animal venoms contain components that affect various stages of nerve impulse transduction, including the release of the neurotransmitter, its interaction with the receptor, signal transmission in the nerve fiber, and other stages. Some mechanisms of neurotoxic action are well described, such as the interaction of snake postsynaptic neurotoxins with nicotinic acetylcholine receptors. However, even in this case, not all the details of the interaction have been elucidated. Other mechanisms are not as clear and require more detailed study, such as the effect of presynaptic neurotoxins on the release of a neurotransmitter. Currently, the standard treatment for animal envenoming is antivenom therapy. However, a huge number of neurotoxins are small proteins (e.g., snake alpha-neurotoxins) or peptides (e.g., alpha-conotoxins), which creates problems in obtaining anti-serum. In this Special Issue, we plan to consider the structures of new neurotoxins and their biological targets, the mechanisms of interaction of neurotoxins with targets, possible ways to prevent the neurotoxic effects of animal venoms, and the molecular mechanisms of such anti-neurotoxic effects. Original articles, reviews, comments, etc. on various aspects of the neurotoxic effects of animal venoms are invited.
Dr. Yuri Utkin
Manuscript Submission Information
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- animal venoms
- biological targets
- molecular mechanisms