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Nutrients and Nitrite
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Nutrients and Nitrite

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: closed (31 January 2022) | Viewed by 6556

Special Issue Editors

Prof. Dr. Jun Kobayashi

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Guest Editor
Department of Clinical Dietetics and Human Nutrition, Faculty of Pharmaceutical Science, Josai University, 1-1 Keyakidai, Sakado 350-0295, Japan
Interests: nitric oxide; nitrate/nitrite; crush syndrome; ischemia/reperfusion injury; reactive oxygen species
Special Issues, Collections and Topics in MDPI journals
Dr. Isamu Murata

E-Mail Website
Guest Editor
Laboratory of Pharmacotherapeutics and neuropsychopharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, Keyakidai 1-1, Sakado, Saitama 350-0295, Japan
Interests: nitric oxide; ischemia/reperfusion injury; crush syndrome
Dr. Kazuo Ohtake

E-Mail Website
Guest Editor
Laboratory of Physiology, Faculty of Pharmaceutical Sciences, Josai University, 1–1 Keyakidai, Sakado, Saitama 350-0295, Japan
Interests: cell physiology; molecular biology; exercise physiology; nitric oxide; omega-3 fatty acids
Special Issues, Collections and Topics in MDPI journals
Dr. Kunihiro Sonoda

E-Mail Website
Guest Editor
Department of Food and Nutritional Environment, College of Human Life and Environment, Kinjo Gakuin University, Nagoya, Japan
Interests: nutrition; nitrite; nitrate; nitric oxide; hypertension; cardiology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Although nitrate and nitrite were previously considered to be inert end products of endogenously produced nitric oxide (NO) in the process of NO oxygenation, they are now known to be physiologically recycled in the blood and tissue to form NO and other bioactive nitrogen oxides. Decreased NO availability, caused by obesity and endothelial dysfunction, might be causally related to the development of lifestyle-related diseases, such as insulin resistance, ischemic heart disease, and hypertension. However, dietary intake of nitrite as a nutrient may compensate NO synthase (NOS)-dependent NO generation through the enterosalivary nitrate-nitrite-NO pathway by transmitting NO activity in various molecular forms, including NO and protein S-nitrosothiols. Potential topics in this special issue may include the above-mentioned metabolic disorders but are not limited to the association of nitrite-mediated NO activity with lifestyle-related diseases. We would also like to extend the concept of this theme to the field of sports and exercise, maternal nutrition, breastfeeding during the perinatal period, and even to infectious diseases, including COVID-19, in which NO-mediated molecular mechanisms may be beneficially involved. In this special issue, we look forward to discussions on the prophylactic and therapeutic effects of nitrite intake as a nutrient in a variety of pathophysiological conditions.

Prof. Jun Kobayashi
Dr. Isamu Murata
Dr. Kazuo Ohtake
Dr. Kunihiro Sonoda
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nitrate and nitrite
  • nitric oxide (NO)
  • enterosalivary-nitrate-nitrite-NO pathway
  • microbial flora
  • mitochondrial electron transport chain
  • nitrosylation
  • nitrosation
  • ischemia/reperfusion injury
  • oxidative stress
  • crush syndrome
  • breastfeeding
  • lifestyle-related diseases
  • COVID-19

Published Papers (2 papers)

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Research

16 pages, 3258 KiB  
Article
Beneficial Effects of Dietary Nitrite on a Model of Nonalcoholic Steatohepatitis Induced by High-Fat/High-Cholesterol Diets in SHRSP5/Dmcr Rats: A Preliminary Study
by Kunihiro Sonoda, Yuka Kono, Kazuya Kitamori, Kazuo Ohtake, Sachiko Shiba, Keizo Kasono and Jun Kobayashi
Int. J. Mol. Sci. 2022, 23(6), 2931; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms23062931 - 08 Mar 2022
Cited by 2 | Viewed by 2112
Abstract
Nonalcoholic steatohepatitis (NASH) is a chronic liver disease that leads to liver cirrhosis and hepatocellular carcinoma. Endothelial dysfunction caused by hepatic lipotoxicity is an underlying NASH pathology observed in the liver and the cardiovascular system. Here, we evaluated the effect of dietary nitrite [...] Read more.
Nonalcoholic steatohepatitis (NASH) is a chronic liver disease that leads to liver cirrhosis and hepatocellular carcinoma. Endothelial dysfunction caused by hepatic lipotoxicity is an underlying NASH pathology observed in the liver and the cardiovascular system. Here, we evaluated the effect of dietary nitrite on a rat NASH model. Stroke-prone, spontaneously hypertensive 5/Dmcr rats were fed a high-fat/high-cholesterol diet to develop the NASH model, with nitrite or captopril (100 mg/L, each) supplementation in drinking water for 8 weeks. The effects of nitrite and captopril were evaluated using immunohistochemical analyses of the liver and heart tissues. Dietary nitrite suppressed liver fibrosis in the rats by reducing oxidative stress, as measured using the protein levels of nicotinamide adenine dinucleotide phosphate oxidase components and inflammatory cell accumulation in the liver. Nitrite lowered the blood pressure in hypertensive NASH rats and suppressed left ventricular chamber enlargement. Similar therapeutic effects were observed in a captopril-treated rat NASH model, suggesting the possibility of a common signaling pathway through which nitrite and captopril improve NASH pathology. In conclusion, dietary nitrite attenuates the development of NASH with cardiovascular involvement in rats and provides an alternative NASH therapeutic strategy. Full article
(This article belongs to the Special Issue Nutrients and Nitrite)
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19 pages, 2513 KiB  
Article
Modulation of Insulin Resistance, Dyslipidemia and Serum Metabolome in iNOS Knockout Mice following Treatment with Nitrite, Metformin, Pioglitazone, and a Combination of Ampicillin and Neomycin
by Hobby Aggarwal, Priya Pathak, Yashwant Kumar, Kumaravelu Jagavelu and Madhu Dikshit
Int. J. Mol. Sci. 2022, 23(1), 195; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms23010195 - 24 Dec 2021
Cited by 8 | Viewed by 3299
Abstract
Oxidative and nitrosative stress plays a pivotal role in the incidence of metabolic disorders. Studies from this lab and others in iNOS-/- mice have demonstrated occurrence of insulin resistance (IR), hyperglycemia and dyslipidemia highlighting the importance of optimal redox balance. The present [...] Read more.
Oxidative and nitrosative stress plays a pivotal role in the incidence of metabolic disorders. Studies from this lab and others in iNOS-/- mice have demonstrated occurrence of insulin resistance (IR), hyperglycemia and dyslipidemia highlighting the importance of optimal redox balance. The present study evaluates role of nitrite, L-arginine, antidiabetics (metformin, pioglitazone) and antibiotics (ampicillin-neomycin combination, metronidazole) on metabolic perturbations observed in iNOS-/- mice. The animals were monitored for glucose tolerance (IPGTT), IR (insulin, HOMA-IR, QUICKI), circulating lipids and serum metabolomics (LC-MS). Hyperglycemia, hyperinsulinemia and IR were rescued by nitrite, antidiabetics, and antibiotics treatments in iNOS-/- mice. Glucose intolerance was improved with nitrite, metformin and pioglitazone treatment, while ampicillin-neomycin combination normalised the glucose utilization in iNOS-/- mice. Increased serum phosphatidylethanolamine lipids in iNOS-/- mice were reversed by metformin, pioglitazone and ampicillin-neomycin; dyslipidemia was however marginally improved by nitrite treatment. The metabolic improvements were associated with changes in selected serum metabolites-purines, ceramide, 10-hydroxydecanoate, glucosaminate, diosmetin, sebacic acid, 3-nitrotyrosine and cysteamine. Bacterial metabolites-hippurate, indole-3-ethanol; IR marker-aminoadipate and oxidative stress marker-ophthalmate were reduced by pioglitazone and ampicillin-neomycin, but not by nitrite and metformin treatment. Results obtained in the present study suggest a crucial role of gut microbiota in the metabolic perturbations observed in iNOS-/- mice. Full article
(This article belongs to the Special Issue Nutrients and Nitrite)
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