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Special Issue "Notch Signaling in Blood and Lymphatic Vascular Anomalies"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 30 November 2021.

Special Issue Editors

Dr. Carrie Shawber
E-Mail Website
Guest Editor
Departments of Obsterics and Gynecology, and Surgery, Vagelos College of Physcians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA
Interests: lymphatic and vascular development; vascular malformations; Notch signaling; transgenic mouse modeling; genetics; Notch therapeutic development
Dr. June K. Wu
E-Mail Website
Guest Editor
Department of Surgery, Vagelos College of Physcians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA
Interests: vascular anomalies; vascular malformations; hemangiomas; Notch signalling; clinical outcomes

Special Issue Information

Dear Colleagues,

Vascular anomalies are a large set of heterogenous vascular diseases consisting of vascular tumors and malformations of the blood and lymphatic systems that result in numerous deleterious morbidities. They often present in utero or shortly after birth, suggesting that defects in vascular specification and patterning contribute to the development of vascular anomalies. Inherited or de novo germline and somatic mutations in cancer genes have been shown to contribute to the development of vascular anomalies, helping to guide current interventions. However, these interventions are often not curative. In recent years, dysregulation of Notch signaling, a key regulatory pathway in the development of the blood and lymphatic vascular systems, has been implicated in the pathogenesis of multiple vascular anomalies, including arteriovenous malformations, infantile hemangiomas, cerebral cavernous malformations, and primary lymphedema. A number of therapeutics that target the Notch signaling pathway are in clinical development or trials for the treatment of cancers. Although these therapeutics may be of utility in patients with vascular anomalies, this depends on a better understanding of the role of Notch in vascular anomaly pathogenesis and genetics.

The goal of this Special Issue, entitled “Notch Signaling in Blood and Lymphatic Vascular Anomalies”, of the International Journal of Molecular Sciences is to be a bridge between the basic and translational research looking into the role of Notch in the pathobiology of vascular anomalies and the use of Notch therapies to reverse its effects. We welcome original research and review papers focused on the molecular science of Notch and vascular anomalies. Pure clinical/investigation studies are not suitable. Potential topics include, but are not limited to, the following:

  1. Notch functions in vascular malformations, including arterial venous malformations and cerebral cavernous malformations;
  2. The role of Notch in vascular tumors, including infantile hemangiomas;
  3. animal models of Notch and vascular anomalies;
  4. the role of pericyte/vascular smooth muscle Notch signaling in vascular anomalies;
  5. Notch genetics in vascular anomalies; and
  6. therapeutic targeting of Notch in vascular anomalies.

Dr. Carrie Shawber
Dr. June K. Wu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Notch signaling
  • Notch ligands, Dll4/Jag1
  • vascular anomalies
  • vascular malformations
  • vascular tumors
  • Notch therapeutics
  • Notch genetics

Published Papers

This special issue is now open for submission.
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