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Special Issue "Nuclear Envelope Proteins 2.0"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 31 August 2021.

Special Issue Editor

Dr. James M. Holaska
Guest Editor
Department of Biomedical Sciences, Cooper Medical School of Rowan University, Camden, United States
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

The nuclear envelope functionally separates the nucleoplasm from the cytoplasm. The nuclear envelope is composed of two lipid bilayers—the outer nuclear membrane, which is contiguous with the endoplasmic reticulum, and the inner nuclear membrane. Embedded within the nuclear envelope are the nuclear pore complexes, which provide bi-directional transport across the nuclear membrane. Underlying the inner nuclear membrane is a network of intermediate filament proteins called lamins, which provide the nuclear structure and elasticity.

The outer and inner nuclear membranes are functionally distinct proteinaceous membranes. There are over 100 inner nuclear membrane proteins, many of which are cell type-specific. These proteins have diverse cellular roles, including regulation of nuclear structure, genomic organization, chromatin architecture, gene expression, the cell cycle, and cytoskeletal organization. Given these diverse roles, it is not surprising that mutations in many of these proteins cause or have been linked to many different diseases.

This Special Issue on “Nuclear Envelope Proteins” will contain a selection of research and review articles covering all aspects of nuclear envelope protein structure and function, and will provide mechanistic insight into their function. Studies of nuclear envelope protein function as it relates to disease are also encouraged.

Dr. James M. Holaska
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Nuclear envelope
  • Lamin
  • Emerin
  • Nuclear membrane
  • Inner nuclear membrane (INM)
  • Nuclear envelope transmembrane protein (NET)
  • LEM (Lap2-emerin-MAN1) domain
  • LINC (linker of nucleoskeleton and cytoskeleton)
  • NPC (nuclear pore complex)
  • Lamina-associated domain (LAD)

Published Papers

This special issue is now open for submission.
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