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Special Issue "Nutraceuticals in Cardiovascular and Metabolic Diseases"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 31 July 2021.

Special Issue Editors

Dr. Maurizio Forte
E-Mail Website
Guest Editor
Department of Angio-Cardio-Neurology, IRCCS Neuromed, 86077 Pozzilli, Italy
Interests: cardiovascular diseases; autophagy; nutraceuticals; stroke; mitochondrial dysfunction
Dr. Albino Carrizzo
E-Mail Website
Guest Editor
1. Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, 84081 Baronissi, Italy
2. Department of Vascular Physiopathology, IRCCS Neuromed, 86077 Pozzilli, Italy
Interests: cardiovascular diseases; blood pressure; nitric oxide signaling; oxidative stress
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Cardiovascular and metabolic diseases, including heart failure, atherosclerosis, and metabolic syndrome, are serious health issues that affect the general population worldwide. Lifestyle improvements and improved nutrition appear to be efficacious strategies for reducing the effects of cardio-metabolic diseases and their associated risk factors. Nutraceuticals exert promising health-promoting effects, both for prevention of disease and to support current therapies, as observed in preclinical and clinical studies. The reduction of oxidative stress is one of the target mechanisms common to many nutraceuticals, but compelling evidence has also shown the ability of these molecules to modulate additional signalling, such as cell clearing systems, mitochondrial metabolism, and nutrient sensing pathways, which are usually dysregulated in cardiovascular and metabolic diseases. However, many aspects concerning the use of nutraceuticals in human diseases should be further clarified. Plasma bioavailability and tissue distribution after intake are not well characterized for many nutraceuticals, and the molecular mechanisms underlying their beneficial effects are not fully understood. The identification of new nutraceuticals in natural sources is also encouraged.

This Special Issue will focus on the role of nutraceuticals in cardiovascular and metabolic diseases. We invite authors to submit original articles covering studies performed as basic research, applied research, pre-clinical models of diseases, and review articles.

Dr. Maurizio Forte
Dr. Albino Carrizzo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • nutraceuticals
  • cardiovascular diseases
  • metabolic diseases
  • oxidative stress
  • bioactive compounds
  • metabolic syndrome
  • heart failure
  • diabetes
  • vascular dysfunction
  • atherosclerosis

Published Papers (1 paper)

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Open AccessReview
Obesity, Nutrition and Heart Rate Variability
Int. J. Mol. Sci. 2021, 22(8), 4215; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22084215 - 19 Apr 2021
Viewed by 337
Heart rate variability (HRV) represents the activity and balance of the autonomic nervous system and its capability to react to internal and external stimuli. As a measure of general body homeostasis, HRV is linked to lifestyle factors and it is associated with morbidity [...] Read more.
Heart rate variability (HRV) represents the activity and balance of the autonomic nervous system and its capability to react to internal and external stimuli. As a measure of general body homeostasis, HRV is linked to lifestyle factors and it is associated with morbidity and mortality. It is easily accessible by heart rate monitoring and gains interest in the era of smart watches and self-monitoring. In this review, we summarize effects of weight loss, training, and nutrition on HRV with a special focus on obesity. Besides weight reduction, effects of physical activity and dietary intervention can be monitored by parameters of HRV, including its time and frequency domain components. In the future, monitoring of HRV should be included in any weight reduction program as it provides an additional tool to analyze the effect of body weight on general health and homeostasis. HRV parameters could, for example, be monitored easily by implementation of an electrocardiogram (ECG) every two to four weeks during weight reduction period. Indices presumibly showing beneficial changes could be a reduction in heart rate and the number of premature ventricular complexes as well as an increase in standard deviation of normal-to-normal beat intervals (SDNN), just to name some. Full article
(This article belongs to the Special Issue Nutraceuticals in Cardiovascular and Metabolic Diseases)
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