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Omics Techniques for Toxins Research 2.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Toxicology".

Deadline for manuscript submissions: closed (24 February 2022) | Viewed by 4427

Special Issue Editor

Faculty of Medicine, University Juraj Dobrila of Pula, 52100 Pula, Croatia
Interests: proteomics; foodborne pathogens; mechanisms of bacterial resistance; extracellular vesicles
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear colleagues,

According to the Center for Disease Control and Prevention (CDC), antibiotic resistance is one of the biggest public health challenges of our time. Each year in the U.S., at least 2 million people get an antibiotic-resistant infection, and at least 23,000 people die (https://www.cdc.gov/drugresistance/index.html). In Europe, we are facing a similar situation. Sepsis and septic shock are frequent causes of deaths as a consequence of infection with resistant bacteria. Exotoxins of clinically relevant bacteria such as hemolysins can significantly impair organ functions. 

On the other hand, there are more as 250 microbial pathogens known to cause food-borne illnesses. Accidents with food of mostly animal origin, and traditional fermented food products, have recently accompanied numerous cases that have occurred as a consequence of contaminations of fresh and processed food.

Microbial infection may also cause contamination with mycotoxins, bacteria, and other toxins in food, and sometimes in the environment. Omics methods such as proteomics, peptidomics, and metabolomics techniques are newly developed tolls that can help to solve the abovementioned problems. Genome, proteome, lipidome, and metabolome analyses of hosts and pathogens and their metabolites in combination with already established laboratory analyses provide reliable information about pathogen activities during infection, outbreaks of disease, and healing periods. Importantly, functionally relevant proteins and products of metabolism are identified in order to trace abovementioned diseases. Fast diagnosis is an additional critical point and in-vivo genomic, proteomic, and metabolomic data can be crucial to guide further functional analysis efficiently. It raises the importance of high-throughput omics analyses and the detection of toxins and other biomarkers of their action during disease progress that will be one of key points in this Special Issue.

Prof. Dr. Djuro Josic
Guest Editor

Manuscript Submission Information

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Keywords

  • Omics
  • Genomics
  • Proteomics
  • Metabolomics
  • Bacterial toxins
  • Mycotoxins
  • Sepsis
  • Septic shock
  • Food poisoning
  • High-throughput analyses

Published Papers (1 paper)

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Review

17 pages, 1326 KiB  
Review
Fighting Cancer with Bacteria and Their Toxins
by Dragan Trivanović, Krešimir Pavelić and Željka Peršurić
Int. J. Mol. Sci. 2021, 22(23), 12980; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms222312980 - 30 Nov 2021
Cited by 10 | Viewed by 3747
Abstract
Cancer is one of the most important global health problems that continues to demand new treatment strategies. Many bacteria that cause persistent infections play a role in carcinogenesis. However, since bacteria are well studied in terms of molecular mechanisms, they have been proposed [...] Read more.
Cancer is one of the most important global health problems that continues to demand new treatment strategies. Many bacteria that cause persistent infections play a role in carcinogenesis. However, since bacteria are well studied in terms of molecular mechanisms, they have been proposed as an interesting solution to treat cancer. In this review, we present the use of bacteria, and particularly bacterial toxins, in cancer therapy, highlighting the advantages and limitations of bacterial toxins. Proteomics, as one of the omics disciplines, is essential for the study of bacterial toxins. Advances in proteomics have contributed to better characterization of bacterial toxins, but also to the development of anticancer drugs based on bacterial toxins. In addition, we highlight the current state of knowledge in the rapidly developing field of bacterial extracellular vesicles, with a focus on their recent application as immunotherapeutic agents. Full article
(This article belongs to the Special Issue Omics Techniques for Toxins Research 2.0)
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