Special Issue "Intracellular Organelle Rearrangement Induced by Pathogenic Infections"
Deadline for manuscript submissions: closed (31 March 2021).
Interests: viral replication organelle; viral assembly; viral budding; selective autophagy; endoplasmic reticulum membrane rearrangement; innate immune responses
Many pathogens have evolved to assume an intracellular mode of infection for their growth and replication; however, several intracellular antipathogen responses potentially prevent the growth of pathogens, or sometimes these responses lead to the elimination of intracellular pathogens. Recent studies have reported that molecules localized in organelle regulate these antipathogen responses, and intracellular pathogens induce the dynamic rearrangement of organelles to modify or sometimes neutralize its functions for their efficient growth. For example, some bacteria modify lysosomal membrane components for their propagation within these intracellular compartments. Several viruses remodel the endoplasmic reticulum or Golgi membranes and generate a new intracellular compartment for efficient replication of their genome and viral assembly. Furthermore, some bacteria modify autophagic machinery to disable the antibacterial response of the cell, and viruses damage mitochondrial proteins involved in innate immune signaling to neutralize antiviral responses.
This Special Issue focuses on organellar rearrangement resulting from the competitive survival of intracellular parasites and to understand the molecular mechanisms underlying the development of novel antipathogen strategies.
Dr. Eiji Morita
Manuscript Submission Information
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- Organellar rearrangement
- Intracellular pathogenic infection
- Anti-innate immune response
- Pathogen-inducing organelle
- Cellular stress responses