Special Issue "The Role of Oxidative Stress Biomarkers in Translational Clinical Research: From the Bench to Bedside"
Deadline for manuscript submissions: 31 October 2021.
Interests: oxidative stress-induced DNA damage and its repair in cardiometabolic and cancer diseases
Special Issues and Collections in MDPI journals
Special Issue in International Journal of Molecular Sciences: DNA Damage and Repair in Degenerative Diseases 2014
Special Issue in International Journal of Molecular Sciences: DNA Damage and Repair in Degenerative Diseases 2016
Special Issue in International Journal of Molecular Sciences: DNA Injury and Repair Systems
Special Issue in International Journal of Molecular Sciences: DNA Damage and Repair in Biology and Medicine
Biomedical research has spent decades, since the definition of oxidative stress, demonstrating the implications of the alterations in redox metabolism (oxi-reductive stress (ORS) in the physiopathogenesis of multiple diseases and even today the potential of their byproducts as clinical markers has not been successfully validated and thus poorly recognized by clinicians as such. A plethora of different ORS byproducts and selective methodologies are available which enables their assay with enough reproducibility, specificity and sensitivity. Among the oxidative stress markers are many molecules of diverse nature, such as lipid peroxides, oxidized proteins, antioxidants and even the modified bases of DNA and their repair systems, in addition to more recently discovered miRNAs and other related molecules. All of them have potential and should be useful to track different pathologies. However, they have not been commercialized by the pharmaceutical and chemical industry as laboratory tests for their clinical use in the diagnosis and monitoring of diseases. Undoubtedly, the link that remains to be chained in the transition process from the bench to the bedside depends on its evaluation and certification as a sanitary product by the competent institutions and thus, serving as a guide for the manufacturing companies. This space that remains to be covered requires and must go through the contribution of further research and the development of clinical trials with important cohorts that support the robustness of their conclusions.
Scope of the topic: Researchers in the field of experimental biomedicine. Study of oxy-ductive stress (ORS) markers and their validation as emerging clinical markers in cohorts of healthy population and patients with different pathologies.
Prof. Dr. Guillermo T. Sáez
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- DNA and repair systems
- oxidative metabolism
- lipid peroxides
- enzymatic proteins
- DNA damage