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Special Issue "The Role of Oxidative Stress Biomarkers in Translational Clinical Research: From the Bench to Bedside"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".

Deadline for manuscript submissions: 31 October 2021.

Special Issue Editor

Prof. Dr. Guillermo T. Sáez
E-Mail Website
Guest Editor
Department of Biochemistry and Molecular Biology, Faculty of Medicine and Odontology-INCLIVA, Service of Clinical Analysis, Dr. Peset University Hospital -FISABIO, University of Valencia, Avda. Blasco Ibañez 15, 46010 Valencia, Spain
Interests: oxidative stress-induced DNA damage and its repair in cardiometabolic and cancer diseases
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Special Issue Information

Dear Colleagues,

Biomedical research has spent decades, since the definition of oxidative stress, demonstrating the implications of the alterations in redox metabolism (oxi-reductive stress (ORS) in the physiopathogenesis of multiple diseases and even today the potential of their byproducts as clinical markers has not been successfully validated and thus poorly recognized by clinicians as such. A plethora of different ORS byproducts and selective methodologies are available which enables their assay with enough reproducibility, specificity and sensitivity. Among the oxidative stress markers are many molecules of diverse nature, such as lipid peroxides, oxidized proteins, antioxidants and even the modified bases of DNA and their repair systems, in addition to more recently discovered miRNAs and other related molecules. All of them have potential and should be useful to track different pathologies. However, they have not been commercialized by the pharmaceutical and chemical industry as laboratory tests for their clinical use in the diagnosis and monitoring of diseases. Undoubtedly, the link that remains to be chained in the transition process from the bench to the bedside depends on its evaluation and certification as a sanitary product by the competent institutions and thus, serving as a guide for the manufacturing companies. This space that remains to be covered requires and must go through the contribution of further research and the development of clinical trials with important cohorts that support the robustness of their conclusions.

Scope of the topic: Researchers in the field of experimental biomedicine. Study of oxy-ductive stress (ORS) markers and their validation as emerging clinical markers in cohorts of healthy population and patients with different pathologies.

Prof. Dr. Guillermo T. Sáez
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • DNA and repair systems
  • oxidative metabolism
  • lipid peroxides
  • enzymatic proteins
  • DNA damage

Published Papers (1 paper)

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The Effectiveness of Glutathione Redox Status as a Possible Tumor Marker in Colorectal Cancer
Int. J. Mol. Sci. 2021, 22(12), 6183; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22126183 - 08 Jun 2021
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The role of oxidative stress (OS) in cancer is a matter of great interest due to the implication of reactive oxygen species (ROS) and their oxidation products in the initiation of tumorigenesis, its progression, and metastatic dissemination. Great efforts have been made to [...] Read more.
The role of oxidative stress (OS) in cancer is a matter of great interest due to the implication of reactive oxygen species (ROS) and their oxidation products in the initiation of tumorigenesis, its progression, and metastatic dissemination. Great efforts have been made to identify the mechanisms of ROS-induced carcinogenesis; however, the validation of OS byproducts as potential tumor markers (TMs) remains to be established. This interventional study included a total of 80 colorectal cancer (CRC) patients and 60 controls. By measuring reduced glutathione (GSH), its oxidized form (GSSG), and the glutathione redox state in terms of the GSSG/GSH ratio in the serum of CRC patients, we identified significant changes as compared to healthy subjects. These findings are compatible with the effectiveness of glutathione as a TM. The thiol redox state showed a significant increase towards oxidation in the CRC group and correlated significantly with both the tumor state and the clinical evolution. The sensitivity and specificity of serum glutathione levels are far above those of the classical TMs CEA and CA19.9. We conclude that the GSSG/GSH ratio is a simple assay which could be validated as a novel clinical TM for the diagnosis and monitoring of CRC. Full article
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