Special Issue "Role of Dysregulation of pH in Cancer"
Deadline for manuscript submissions: 30 June 2021.
Interests: membrane proteins; pH regulation; Na+/H+ exchanger
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Cancer is a daunting multitude of diseases that requires a large variety of therapeutic strategies to treat individual types. Of late, however, evidence has suggested that many types of cancer cells and tumors, and perhaps most kinds, have acid–base disturbances that are opposite to the acid–base distribution in normal tissues, with an interstitial acidosis and intracellular elevated pH. This dysregulation of pH has emerged as a hallmark of cancer. In fact, this phenomenon has been referred to as “a perfect storm” for cancer progression, promoting cell growth, invasion, metastasis, and tumor formation. The abnormalities of intracellular alkalinization together with extracellular acidification in solid tumors and other cells appear to be a specific hallmark of malignancy. Several different proteins are involved in pH regulation and proton gradient reversal. These include the Na+/H+ exchangers NHEs (SLC9A family), the Na+HCO3- cotransporter NBCn1 (SLC4A7), anion exchangers, vacuolar-type adenosine triphosphatases, and the lactate, H+ cotransporters of the monocarboxylate family (MCT1 and MCT4 (SLC16A1 and 3). Additionally, carbonic anhydrases contribute to acid transport.
This Special Issue on the “Role of Dysregulation of pH in Cancer” invites papers on this topic. It welcomes papers on the phenomenon itself, the proteins involved and contributing to the disease, their regulation in disease development, their contribution to the malignant process, the development of anticancer drugs that affect the process, and their use in the treatment of cancer. Papers on all forms of cancer are of interest.
Prof. Dr. Larry Fliegel
Manuscript Submission Information
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