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Special Issue "Molecular Aspects of Degeneration and Regeneration in the Peripheral Nervous System"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 31 December 2021.

Special Issue Editor

Dr. Kazunori Sango
E-Mail Website
Guest Editor
Department of Diseases and Infection, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya, Tokyo 156-8506, Japan
Interests: diabetic neuropathy; axonal regeneration; Schwann cells; myelination
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

In the peripheral nervous system, the intrinsic regenerative capacity of neurons coupled with permissive environments due to the activation of Schwann cells and macrophages during Wallerian degeneration contributes to axonal regeneration and reinnervation after injury. However, there is much room for investigation to elucidate the molecules and mechanisms involved in the repair process (e.g., neurotrophic and chemotactic factors, growth inhibitory molecules, and extracellular matrix conctituents), and clinical approaches for accelerating axonal regeneration with functional restoration remain insufficient. In addition, peripheral neuropathies caused by various etiologic mechanisms (e.g., genetic abnormalities, immune system disorders, drugs, diabetes, and other life style-related diseases) are intractable, and pathogenesis-based therapies to treat them have been unsuccessful or incomplete thus far. This Special Issue focuses on recent topics pertinent to the molecular aspects of peripheral nerve degeneration and regeneration following axonal injury; the development and progression of neuropathies; and therapeutic strategies against these lesions, including cell and tissue transplantation and neural interface.

Dr. Kazunori Sango
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • peripheral nerve injury
  • Wallerian degeneration
  • axonal regeneration
  • peripheral neuropathies
  • Schwann cells
  • demyelination
  • remyelination
  • neurotrophic and chemotactic factors
  • growth inhibitory molecules
  • transplantation
  • neural interface

Published Papers

This special issue is now open for submission.
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