Special Issue "Role of Phosphodiesterase in Biology and Pathology"
Deadline for manuscript submissions: closed (31 January 2021).
Interests: signal transduction; PDEs; striated muscle
The Special Issue “The role of Phosphodiesterases in Biology and Pathology” will publish the most exciting articles on the role of phosphodiesterases in health and disease. Review articles, commentaries, and experimental papers are welcome. Phosphodiesterases are ubiquitous enzymes which hydrolyze cAMP and cGMP second messengers in a temporal, spatial, and integrated manner according to their expression and localization inside the cell. cAMP and cGMP signaling regulate a huge variety of cell functions; therefore, phosphodiesterases are involved in any aspect of cell biology. In recent years, further research has focused on the role of these proteins in compartmentalization of the cyclic nucleotide signal in a wide number of cell models. The understanding of cell signaling pathways in which phosphodiesterases are involved is of great importance in cell physiology and human pathology. A great number of pharmaceutical inhibitors are available, and over the past few decades, they have been successfully used in the treatment of impotence and chronic pulmonary diseases. New evidence underlines a possible use of phoshodiesterase inhibitors in the treatment of cardiovascular diseases, type 2 diabetes, cancer, inflammation, and many more other pathologies which have recently been identified.
Dr. Fabio Naro
Prof. Dr. Mario Giorgi
Dr. Manuela Pellegrini
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- signal transduction
- beta-adrenergic receptors
- phosphodiesterase inhibitors
- cardiac diseases
- nervous system