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Special Issue "Amyloid β and Alzheimer’s Disease: Molecular Updates from Physiology to Pathology 2.0"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 15 August 2021.

Special Issue Editor

Dr. Maria Laura Giuffrida
E-Mail Website
Guest Editor
Italian National Research Council, Institute of Crystallography (IC), Catania, Italy
Interests: Alzheimer’s disease; molecular neurobiology; amyloid-β; primary cortical neurons; signal transduction; BDNF; insulin and insulin-like growth factor signaling in Alzheimer's disease; HSP60; Aβ and copper; small molecules and peptide inhibitors of Aβ aggregation
Special Issues and Collections in MDPI journals

Special Issue Information

Dear colleagues,

This Special Issue is the continuation of our previous Special Issue "Amyloid β and Alzheimer’s Disease: Molecular Updates from Physiology to Pathology".

Alzheimer’s disease (AD) is still an incurable disease with an incidence that is expected to increase in the near future. In previous decades, the pathophysiology of AD has been extensively investigated. Several approaches have been employed to disclose the molecular mechanisms underlying the cellular dysfunctions typically observed in AD. From in vitro and in vivo findings, we have learned that Aβ oligomers (AβOs), rather than Aβ fibrils, are mainly responsible for the effects leading to neurodegeneration. They have shown a better correlation with the severity of the disease and, in line with this observation, were found to induce synaptic dysfunction in the early stage of the disease, promote oxidative stress, and interfere with the activation of important cellular receptors. However, besides these unquestionable roles of Aβ oligomers, the primary cause of Aβ over-production and aggregation is far from being completely clarified.

Moreover, after initial evidence that Aβ monomers are innocuous, an increasing amount of data have indicated that Aβ may have important physiological roles in neuronal activity. A more comprehensive understanding of Aβ functions, from physiology to the occurrence of AD pathological conditions, could contribute to the refinement of pharmacological interventions and the design of new drug candidates.

Most AD drugs have been projected to block Aβ production or aggregation. However, the targeting of all Aβ species, including monomers, might be the reason for the continuous failure of clinical trials. The recent encouraging results of antibodies which preferentially bind to toxic AβOs seem to support this view.

The aim of this Special Issue of IJMS is to collect, in a broader perspective, scientific papers as well as reviews of the current literature, that deal with amyloid beta peptide function in health and/or disease. All original works that look at the role of Aβ within and beyond the disease and contribute to the improvement of the molecular understanding of Alzheimer’s disease are welcome.

Dr. Maria Laura Giuffrida
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Alzheimer’s disease
  • Aβ monomers
  • Aβ oligomers
  • signal transduction
  • neuroprotection
  • anti- Aβ therapy

Published Papers

This special issue is now open for submission.
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