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Special Issue "The Effect of Phytochemicals and Food Bioactive Compounds on Diabetes"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 31 May 2021.

Special Issue Editors

Prof. Kazumi Yagasaki
E-Mail Website
Guest Editor
Tokyo University of Agriculture and Technology (TUAT), Japan
Interests: pharmacology; bromacology (=food pharmacology) (cf. bromacology is our neologism); functional foods; biofactors; nutrients; non-nutrients; phytochemicals; zoochemicals; amino acids (BCAA); fatty acids; diabetes; hyperglycemia; hyperuricemia; dyslipidemia; nephritis; hepatoma; animal cell technology; cultured cells; animal model; signaling pathway; transporter, receptor; AMPK; Akt; PKC; GLUT4 etc.
Prof. Dr. Christo J.F. Muller
Co-Guest Editor
Biomedical Research and Innovation Platform, South African Medical Research Council; University of Zululand and Stellenbosch University, South Africa
Interests: metabolic disease (pathophysiology, prevention and treatment); phytotherapeutics and early detection of type 2 diabetes

Special Issue Information

Dear Colleagues,

Diabetes, especially global prevalence of type 2 diabetes (T2D), is increasing as reported in the Diabetes Atlas, 9th edition, (International Diabetes Federation, 2019). In 2019, it is estimates that 463 million people have diabetes, and this number is projected to reach 578 million by 2030, and 700 million by 2045.  Natural products from terrestrial and aquatic organisms still constitute huge sources of biologically active factors for the development of drugs, cosmetics or nutraceuticals as well as our daily foods. Screening antidiabetic components from edible natural products and clarifying their modes of actions are considered to be an intelligent policy from the aspects of safety and diabetes prevention, because they have long histories of ingestion every day. This issue expects recent studies on preventive and/or alleviating effects of various biofactors against diabetes, especially type 2 diabetes (T2D), and diabetes related disorders as well as those on their modes of actions at molecular, cellular, tissue and/or whole-body levels. In this issue, biofactors include both non-nutrients such as various phytochemicals and nutrients, for example, branched-chain amino acids (BCAA), peptides and lipids.

Prof. Kazumi Yagasaki
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • diabetes
  • type 2 diabetes (T2D)
  • insulin resistance
  • myocytes
  • adipocytes
  • pancreatic β cells
  • T2D model animal
  • cellular signaling
  • Akt
  • AMPK
  • GLUTs
  • microarray
  • phytochemicals
  • zoochemicals
  • BCAAs

Published Papers (1 paper)

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Open AccessReview
Activation of Insulin Signaling by Botanical Products
Int. J. Mol. Sci. 2021, 22(8), 4193; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22084193 - 18 Apr 2021
Viewed by 277
Type 2 diabetes (T2D) is a worldwide health problem, ranked as one of the leading causes for severe morbidity and premature mortality in modern society. Management of blood glucose is of major importance in order to limit the severe outcomes of the disease. [...] Read more.
Type 2 diabetes (T2D) is a worldwide health problem, ranked as one of the leading causes for severe morbidity and premature mortality in modern society. Management of blood glucose is of major importance in order to limit the severe outcomes of the disease. However, despite the impressive success in the development of new antidiabetic drugs, almost no progress has been achieved with regard to the development of novel insulin-sensitizing agents. As insulin resistance is the most eminent factor in the patho-etiology of T2D, it is not surprising that an alarming number of patients still fail to meet glycemic goals. Owing to its wealth of chemical structures, the plant kingdom is considered as an inventory of compounds exerting various bioactivities, which might be used as a basis for the development of novel medications for various pathologies. Antidiabetic activity is found in over 400 plant species, and is attributable to varying mechanisms of action. Nevertheless, relatively limited evidence exists regarding phytochemicals directly activating insulin signaling, which is the focus of this review. Here, we will list plants and phytochemicals that have been found to improve insulin sensitivity by activation of the insulin signaling cascade, and will describe the active constituents and their mechanism of action. Full article
(This article belongs to the Special Issue The Effect of Phytochemicals and Food Bioactive Compounds on Diabetes)
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