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Special Issue "Air Pollution and Health Risks with a Special Emphasis to Cardiovascular Risk"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Toxicology".

Deadline for manuscript submissions: 28 February 2022.

Special Issue Editor

Prof. Dr. Alpo Vuorio
E-Mail Website
Guest Editor
1 Mehiläinen Airport Health Centre, 01530, Vantaa, Finland 2 University of Helsinki, Department of Forensic Medicine, 00014, Helsinki, Finland
Interests: atherosclerosis, familial hypercholesterolemia, LDL, Lp(a), environment, safety
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Special Issue Information

Dear Colleagues,

In many major cities, urban air is polluted due to particulate matter and toxic gases. Long-term and short-term exposures to particulate matter are linked to cardiovascular disease, including myocardial infarction, probably via pro-inflammatory and prothrombotic pathways. Toxic chemicals linked to cardiovascular disease are carbon monoxide (CO), nitrogen oxide (NO2), ozone (O3), and sulphurdioxide (SO2).

Recent research has convincingly shown the association between air pollution and cardiovascular disease. The impact of pollution in city centers is clear, as it is almost doubling the risk of coronary artery calcification in middle-aged asymptomatic citizens.  Furthermore, it has been found that variations in pollution levels may affect the mortality rates.

Elderly with pre-existing cardiovascular disease represent the most vulnerable group at risk from air pollution exposure. Suggestions to limit the time spent outdoors to reduce the infiltration of air pollution have been made. On the population level, it has been shown that life will expectancy improve if the air quality is controlled.

This Special Issue will focus on the cellular and genetic mechanisms like

  • Endothelial barrier disruption
  • Tissue inflammation
  • Vasoconstriction
  • Thrombosis
  • Secondary tissue responses (like plaque instability)

Behind the following clinical topics:

  • Impact of air pollution as an acute and long-term cardiovascular risk factor
  • Cardiovascular mortality caused by air pollution
  • Potential preventive measures for air pollution and social programs to reduce the cardiovascular risk
  • Impact of traffic- and industry-caused air pollution and cardiovascular risk
  • Elderly as a group at risk of air pollution-dependent cardiovascular disease
  • Costs caused to the society by air pollution and the related increased cardiovascular risk

In addition to air pollution to cardiovascular risk, this Special Issue welcomes research related air pollution and other diseases:

  • Respiratory and lung diseases
  • Leukemia
  • Birth defects
  • Immune system defects
  • Stroke
  • Neurobehavioral disorders and developmental deficits
  • Cancer

Prof. Dr. Alpo Vuorio
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • air pollution
  • cardiovascular risk
  • coronary artery calcification
  • mortality
  • toxic gases
  • particulate matter
  • elderly
  • respiratory and lung diseases
  • leukemia
  • birth defects
  • immune system defects
  • stroke
  • neurobehavioral disorder
  • development deficits
  • cancer
  • COVID-19

Published Papers (1 paper)

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Blood Plasma’s Protective Ability against the Degradation of S-Nitrosoglutathione under the Influence of Air-Pollution-Derived Metal Ions in Patients with Exacerbation of Heart Failure and Coronary Artery Disease
Int. J. Mol. Sci. 2021, 22(19), 10500; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms221910500 - 28 Sep 2021
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One of the consequences of long-term exposure to air pollutants is increased mortality and deterioration of life parameters, especially among people diagnosed with cardiovascular diseases (CVD) or impaired respiratory system. Aqueous soluble inorganic components of airborne particulate matter containing redox-active transition metal ions [...] Read more.
One of the consequences of long-term exposure to air pollutants is increased mortality and deterioration of life parameters, especially among people diagnosed with cardiovascular diseases (CVD) or impaired respiratory system. Aqueous soluble inorganic components of airborne particulate matter containing redox-active transition metal ions affect the stability of S-nitrosothiols and disrupt the balance in the homeostasis of nitric oxide. Blood plasma’s protective ability against the decomposition of S-nitrosoglutathione (GSNO) under the influence of aqueous PM extract among patients with exacerbation of heart failure and coronary artery disease was studied and compared with a group of healthy volunteers. In the environment of CVD patients’ plasma, NO release from GSNO was facilitated compared to the plasma of healthy controls, and the addition of ascorbic acid boosted this process. Model studies with albumin revealed that the amount of free thiol groups is one of the crucial factors in GSNO decomposition. The correlation between the concentration of NO released and -SH level in blood plasma supports this conclusion. Complementary studies on gamma-glutamyltranspeptidase activity and ICP-MS multielement analysis of CVD patients’ plasma samples in comparison to a healthy control group provide broader insights into the mechanism of cardiovascular risk development induced by air pollution. Full article
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