Special Issue "Molecular Mechanisms of Polyglutamine Diseases"
Deadline for manuscript submissions: 30 September 2021.
Polyglutamine diseases comprise a group of nine inherited neurodegenerative disorders caused by an abnormal mutation of a CAG tract within the coding region of the causative gene. This abnormal repetition codifies for an abnormal glutamine tract in the respective protein, which tends to aggregate, forming intraneuronal inclusions that are a neuropathological feature of these diseases. Currently, there is no cure to stop or delay disease progression, which culminates with the death of the patients.
The genetic basis for the diseases is established, however, the molecular mechanisms leading to the neuronal dysfunction and degeneration observed in selected regions of the brain of these patients are not completely characterized. This knowledge is important to better design and test new therapies that could represent a hope for the patients and an opportunity to stop the disease progression.
In these special number, we expect to gather a group of research studies and reviews aiming to advance the current knowledge of polyglutamine disease molecular mechanisms, but also providing a view of potential treatments and future clinical trials.
Prof. Dr. Clévio Nóbrega
Manuscript Submission Information
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- Polyglutamine diseases
- Huntington’s disease
- Spinocerebellar ataxias
- Disease mechanisms
- Disease models
- Therapeutic approaches