Special Issue "The Promise of Precision Oncology 2.0: Molecular Strategies, Methods, Pharmacogenomics and Informatics"
Deadline for manuscript submissions: 15 December 2021.
Interests: PARP; DNA repair; BRCA1; BRCA2; EGFR; synthetic lethality; experimental therapeutics; breast cancer; ovarian cancer; prostate cancer; head and neck cancer
Precision medicine is an increasingly critical aspect of cancer care for our patients. Existing models use genomics to tailor patient treatment based on the presence of actionable tumor driver mutations. Using tumor sequencing to direct therapy has yielded promising results in some tumor types and driver pathways such that the paradigm for some cancer treatment is changing from being cancer subtype-specific to pathway-based. However, precision oncology is much more complex than simply assaying tumors for driver pathways as success is limited. Technological and scientific advances have allowed for more extensive molecular testing in addition to tumor DNA and RNA sequencing. This Special Issue of IJMS will review the successes and pitfalls of current precision oncology strategies, novel methods to analyze and incorporate large multi-dimensional datasets, pharmacogenomic considerations in personalizing therapy, the potential for drug repurposing, and the promise of artificial intelligence/informatics-based systems to aid in decision support. Research articles on these topics are also welcome.
Prof. Dr. Eddy Shih-Hsin Yang
Manuscript Submission Information
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