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Special Issue "Primary Intraocular Tumors–Molecular Mechanisms, Novel Therapeutic Strategies and Targets"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: 31 January 2022.

Special Issue Editors

Dr. Jacqueline Reinhard
E-Mail Website
Guest Editor
Department of Cell Morphology and Molecular Neurobiology, Ruhr-University Bochum, Bochum, Germany
Interests: chemoresistance; extracellular matrix; molecular signaling; retinoblastoma; tumor niche microenvironment; therapeutic options; tumor stem cells
Dr. Vinodh Kakkassery
E-Mail Website
Guest Editor
Department of Ophthalmology, University of Luebeck, Luebeck, Germany
Interests: chemotherapy resistance; intraocular tumors; ocular oncology; retinoblastoma; uveal melanoma; vitreoretinal lymphoma

Special Issue Information

Dear Colleagues,

Primary intraocular tumors, such as retinoblastoma, uveal melanoma, and primary vitreoretinal lymphoma, are an indescribable burden for patients by threatening sight and survival at the same time. Most likely local tumor control/metastasis prevention, eye salvage, and sight preservation are common objectives in these cancers. In order to improve the care of patients, this Special Issue invites authors to submit comprehensive molecular biological work regarding possible future improvements in diagnostics or/and therapy, displaying up-to-date knowledge and application thereof. Experts in the field will be invited to present their research, which will provide new insights into the current state of inter alia molecular patho- and signaling mechanisms, the identification of novel molecular biomarkers, and innovative targeted therapeutic options.

Dr. Jacqueline Reinhard
Dr. Vinodh Kakkassery
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Animal/cell culture models
  • Biomarker
  • Intraocular tumors
  • Molecular signaling
  • Proteomics
  • Retinoblastoma
  • Therapy approaches
  • Tumorigenesis
  • Uveal melanoma
  • Vitreoretinal lymphoma

Published Papers (1 paper)

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Research

Article
KIT Expression Is Regulated by DNA Methylation in Uveal Melanoma Tumors
Int. J. Mol. Sci. 2021, 22(19), 10748; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms221910748 - 04 Oct 2021
Viewed by 365
Abstract
Uveal melanoma (UM) is an ocular tumor with a dismal prognosis. Despite the availability of precise molecular and cytogenetic techniques, clinicopathologic features with limited accuracy are widely used to predict metastatic potential. In 51 UM tissues, we assessed a correlation between the expression [...] Read more.
Uveal melanoma (UM) is an ocular tumor with a dismal prognosis. Despite the availability of precise molecular and cytogenetic techniques, clinicopathologic features with limited accuracy are widely used to predict metastatic potential. In 51 UM tissues, we assessed a correlation between the expression of nine proteins evaluated by immunohistochemistry (IHC) (Melan-A, S100, HMB45, Cyclin D1, Ki-67, p53, KIT, BCL2, and AIFM1) and the presence of UM-specific chromosomal rearrangements measured by multiplex ligation-dependent probe amplification (MLPA), to find IHC markers with increased prognostic information. Furthermore, mRNA expression and DNA methylation values were extracted from the whole-genome data, achieved by analyzing 22 fresh frozen UM tissues. KIT positivity was associated with monosomy 3, increasing the risk of poor prognosis more than 17-fold (95% CI 1.53–198.69, p = 0.021). A strong negative correlation was identified between mRNA expression and DNA methylation values for 12 of 20 analyzed positions, five located in regulatory regions of the KIT gene (r = −0.658, p = 0.001; r = −0.662, p = 0.001; r = −0.816; p < 0.001; r = −0.689, p = 0.001; r = −0.809, p < 0.001, respectively). DNA methylation β values were also inversely associated with KIT protein expression (p = 0.001; p = 0.001; p = 0.015; p = 0.025; p = 0.002). Our findings, showing epigenetic deregulation of KIT expression, may contribute to understanding the past failure to therapeutically target KIT in UM. Full article
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